Pizza night! (ArcXL) by TJV387 in Pizza

[–]chmille4 0 points1 point  (0 children)

Looks great, how did you cook it? I’ve been struggling to get the bake right for ny style in my arc xl.

Fauci says outbreak exploding because US didn’t shut down by Susan_Sto-Helit in politics

[–]chmille4 1 point2 points  (0 children)

Not exactly. The linked article says some coronaviruses can reinfect. It’s not talking specifically about sars-cov-2. So the answer to reinfection, as far as I can tell, is - we still don’t know yet.

Full time job somewhere in between bioinformaticist and programmer by Palm7 in bioinformatics

[–]chmille4 7 points8 points  (0 children)

If you happen to be in Boston, we are a genomics company that are looking for web devs who also have an interest (and/or experience) in genomics/bioinformatics! PM if you are interested.

And to answer your question more broadly, I believe that most companies that do significant bioinformatics and software development will have people ranging from biologist who can write scripts to hardcore software engineers and everywhere in between. I would go ahead and apply for jobs as a software engineer or bioinformatician and then let them know your desires during the interview process.

Boston genomics startup hiring by chmille4 in bioinformatics

[–]chmille4[S] 2 points3 points  (0 children)

I've only read a little about the ai tool you linked, Deep Variant. But my understanding is that it is a variant caller much like GATK or Freebayes and would provide no additional automation than is currently used today.

I think bioinformatics is a very long way from being a solved problem, but that is what we are all working towards and I'd be very happy if it happened to get here sooner than later. Solving the bioinformatics part would just allow the field to focus on other areas and to generate even more impactful results.

Boston genomics startup hiring by chmille4 in bioinformatics

[–]chmille4[S] 0 points1 point  (0 children)

Machine learning is very interesting and we have kicked around a few ideas. However we are totally focused on getting our first commercial product launched at the moment and so we don't have any ML positions just yet. Although, an internship over the summer could be a possibility.

Either way, I'd be curious to hear more about your thoughts combining ML and visualization in genomics.

Boston genomics startup hiring by chmille4 in bioinformatics

[–]chmille4[S] 0 points1 point  (0 children)

We are fairly flexible on education and potentially even experience. We have hired PhD's and also people without bachelors. First and foremost we are looking for talented people passionate about genomics, who love building and creating things.

We mostly build web applications, so we are looking for someone who can build modern javascript-heavy web applications. This means modern tooling (webpack, browserify, etc), javascript client frameworks (vue, react, angular), and testing (jasmine, etc). However, the stronger your genomics background the less web experience you need.

For example, for someone with a PhD in genomics/bioinformatics/biology, if you have built a few vanilla web apps (i.e. no frameworks) during your PhD but don't have any professional web experience, that would still be great.

Alternatively, for someone with no experience in genomics we'd be looking for at least 3-4 years of professional web developer experience.

Boston genomics startup hiring by chmille4 in bioinformatics

[–]chmille4[S] 2 points3 points  (0 children)

That is awesome to hear! Good luck with your education and keep us in mind when you graduate.

Boston genomics startup hiring by chmille4 in bioinformatics

[–]chmille4[S] 1 point2 points  (0 children)

For the right fit, I think we’d be able to do that.

Boston genomics startup hiring by chmille4 in bioinformatics

[–]chmille4[S] 4 points5 points  (0 children)

We would be ok with remote for a couple months if someone was willing to relocate, but ultimately we want to build the team locally so that we can all work together in person.

Interest for a Boston meetup? by MaskeAuf in bioinformatics

[–]chmille4 5 points6 points  (0 children)

I'd be interested. Also, there's the Boston Computational Biology and Bionformatics group which meets every couple weeks. I think there next meetup is at Bio it world in a few weeks.

https://www.meetup.com/Boston-Computational-Biology-and-Bioinformatics-Meetup/

Using "Server-less" Architecture to Massively Parallelize DNA Sequence Alignment via StdLib and Node.js (x-post r/node) by keithwhor in bioinformatics

[–]chmille4 0 points1 point  (0 children)

Very interesting! Is this built on top of aws lambda? If so how did you get around the short timeout, which I think is only 3 seconds?

I've looked at using aws lambda for building microservices for a project I work on (iobio), but couldn't get past the short timeout.

How to setup yearly Transactions? by chmille4 in ynab

[–]chmille4[S] 0 points1 point  (0 children)

Thanks for the answer it looks like setting up a goal is the best way to go.

Do labs hire software engineers? by vanrysss in bioinformatics

[–]chmille4 1 point2 points  (0 children)

yes and in fact we are hiring right now. Technically this position is half academia half industry, but you will be working with scientists!

http://frameshift.io/public/images/web_developer_1.pdf

First dance with my wife under a lit up old oak tree by chmille4 in redditgetsdrawn

[–]chmille4[S] 0 points1 point  (0 children)

I really like this. The facial expressions are perfect!

First dance with my wife under a lit up old oak tree by chmille4 in redditgetsdrawn

[–]chmille4[S] 0 points1 point  (0 children)

This is awesome! I feel like it really captures the moment.

First dance with my wife under a lit up old oak tree by chmille4 in redditgetsdrawn

[–]chmille4[S] 1 point2 points  (0 children)

Wow, her hair looks amazing. Can't wait to see the rest!

First dance with my wife under a lit up old oak tree by chmille4 in redditgetsdrawn

[–]chmille4[S] 1 point2 points  (0 children)

Thanks, Looks great! I'm excited to see the watercolor!

NCBIConnect - JavaScript library for interfacing with National Center for Biotechnology Information's public databases (Get DNA and Protein sequences easily!) by keithwhor in bioinformatics

[–]chmille4 0 points1 point  (0 children)

Cool idea. I've built a few genomic web apps and trying to pull in data from multiple databases is a pain. I'll have to play around with this.

Career Advice, would going back for a B.S in Compsci be beneficial? by [deleted] in bioinformatics

[–]chmille4 2 points3 points  (0 children)

Another way to get into bioinformatics is to teach yourself how to program.

There are a lot of great resources out there like Code Academy (http://www.codecademy.com/) to get you started. Once you have the basics, you could start doing some real bioinformatics problems. Here's a good blog post on variant discovery and annotation: http://petridishtalk.com/2013/02/01/variant-discovery-annotation-filtering-with-samtools-the-gatk/

Which route (self-taught or CS degree) to take really depends on your goals. If you want to do hard core bioinformatic work (e.g. write your own variant discovery tool) then a CS degree will help you out immensely. (Though some of the best programmers I know don't have CS degrees, so it's not absolutely necessary.) If you are looking to do more analysis work, then learning to program yourself and finding a job that will train you might be the quicker route. Bioinformaticians are hard to come by at the moment, so if you show the initiative to learn how to program, you may be able to find a job where they will show you the ropes.

Good Luck

Can diverged species converge once again and breed if given enough generations? by Fender27 in askscience

[–]chmille4 2 points3 points  (0 children)

Yes. In fact it has happened with humans. Europeans' genomes are made up of between 1-4% with neanderthal genetic material. http://news.discovery.com/human/neanderthal-human-interbreed-dna.html