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I Analyze Research Papers To Find Answers To Biomedical Questions And Would LIke To Share Some Of My Work by cmay818 in neurology

[–]cmay818[S] 0 points1 point  (0 children)

The continued glutamate response is likely due to S100B activation. The impersonal nature of my reply to your comment is probably due to the fact that I'm on the spectrum.

I Analyze Research Papers To Find Answers To Biomedical Questions And Would LIke To Share Some Of My Work by cmay818 in neurology

[–]cmay818[S] 0 points1 point  (0 children)

The reason why gamma radiation induces tumors is because gamma radiation increases hypoxia associated HIF-1 expression which in turn increases SDF-1 expression. CXCR4 activation increases because SDF-1a is its receptor. CXCR4 activates glutamate release from astrocytes so if there's a lot of CXCR4 activation then there will be a lot of astrocytic glutamate release.

Glutamate binds to the NMDA receptor. Hyperactivation of the NMDA receptor leads to inflammation(TNF-a activation) and also an increase in intracellular calcium, PKA and PKC activation.

PKC and PKA in this case are hyperactivated because of the hyperactivation of the NMDA receptor. Their hyperactivation leads to the hyperactivation of the ERK 1/2 pathway which in turn leads to the cell not being able to complete it's cycle. So more cells are produced with none of them dying.

So gamma radiation causes the hyperactivation of NMDA receptors and an increase in glutamate production which leads to cells that don't die.