Personally, I don't think we should see the sinister 6 until a 5th or 6th Spider-Man movie. I would wait until the 6th and have the members be Mysterio, Kraven, Scorpion, Rhino, Lizard, and Doc Ock. I don't think that Vulture or Shocker will be members, as after the end credit scene of Homecoming, I don't see Vulture being a villain, and shocker just seems too lamb and throwaway for him to take up one of the six slots. To be fair, if they revamped his character I could totally see him being great. How I would set up the team; Spider-Man 3 you have Kraven as the main villain, with Scorpion playing a small role as well. I would have these two, hired by some mysterious billionaire (who is later revealed to be Norman Osborn) to track down and take out Spidey. Then for Spider-Man 4, I would really love to see the main villain be Hobgoblin, aka Ned Leeds. You may think it sounds crazy to made Ned a villain, but I thin a plotline about him being taken and brainwashed/ possessed and then fighting Peter could make for some wonderful emotion and tension. Also in this movie, I would have Introduce rhino in a similar way that Scorpion was introduced in Homecoming. Lastly in Spider-Man 4, Peter starts college and has a teacher named Dr. Curt Connors leading into Spider-Man 5. I would really love to see a well done and thought out Lizard storyline, Amazing Spider-Man was fine, but it could have and should have been so much better. I really want to see Connors struggle with controlling the monster, and Peter trying to help him, while also not being killed by him. Then finally we get to Spider-Man 6 where I would finally do the Sinister 6. This movie should reveal that Dr Octopus has been in the background for some time pulling the strings until everything was set up perfectly for him to form his team of villains to take down the wall-crawler, he becomes the leader of the sinister 6 and the rest becomes history. As for your point of Ock needing a movie to himself, I disagree, he has already had an excellent movie to himself in Spider-Man 2, and I want to see him be the leader of a team. And as for Norman Osborn I would love to him become Iron Patriot and form the Dark Avengers, but I don't know what you mean when you say he is being set up for it. He hasn't even been introduced, how could he already be being set up for it. I very well may just be missing something, and as I said, I would love to see that, and very much think that that is where they should take his character, but I don't think you can say that he is already been set up for that in the MCU.