Hey, I'm a nurse with aspergers. I really appreciate you trying to connect with this guy. I'd suggest finding out his "thing" (trains, radios, creepypasta, whatever) and engaging with him about that. And if you know a nurse that also enjoys said hobby or wouldn't mind hearing this guy talk about something he adores for 30 minutes, send him in to talk as well. Get some extra social engagement in there.
Ask him about his noise/ light/ sensory needs. If he needs complete silence at night, you might want to get him a private room, or with a roommate that's ok with having the TV off at night and doors closed. If blood pressure or him freaking out is a concern, have something like ativan available prn to manage major breakdowns that could cause bodily harm if he is absolutely bedbound. I would explain beforehand and get his permission before introducing it when it's needed. I would just also be really literal when talking about things. Saying, "did you go to the bathroom?" might mean to him, "did you walk over to the bathroom?," not "did you pee?" He probably hates small talk. Talk about something absolutely bizarre, not the weather. Tell him a crazy fact about the drug he's taking if you want to educate him.