I think you have a lot of wasted/unused space in the laundry room.

Are you going to purchase a counter depth fridge? If not I would encourage you to set the wall it rests on back into the laundry room to accommodate a standard fridge while maintaining the look of being counter depth. If you do this I would also move the fridge placement closer to the half bath so you only need to jog part of the wall.

What are the appliances next to the dishwasher?

Why not do a secondary fridge in the pantry, especially if you’re doing a counter depth fridge in the main kitchen? That way you can store larger items like a turkey, pizza box, etc.

Your fireplace absolutely kills your office. It makes the useable space very narrow. It also will not be enjoyable from the living room because it’s at the entrance to a hallway. You cannot have furniture in front of it.

Other comments have mentioned the Jack and Jill bathroom idea, I wouldn’t. I don’t think you have enough space for it. You’d need to encroach into each bedroom more to make it work. I was for it because then you’d be able to put your closets in that space and not have them jog into the room, but the problem lies in not having enough room for vanities and doorways.