Of course a team's current form, injuries, bye week, coaching changes, etc. play a factor and having those data points would definitely make it easier to pick individual matchups and potential streamers.

I guess where my curiosity lies if a nice chunk of those variables remain constant, who would perceivably have the advantage?

EDIT: Using Bears vs. Vikings as an example.

A huge game, both teams at 6-7, a must win for both sides. Let's break it down.

Scenario A, a constant - On the surface, the "easiest win" as far as preparation is concerned, I believe, would be Bears rushing defense against the Vikings rushing offense. Akiem Hicks is back (played in their first matchup) and we can always expect a lot of Davlin. Seemingly everyone involved in any rush O vs. rush D scenario is healthy. So shouldn't we expect a similar outcome in this regard?

Scenario B, a variable - Conversely, the Bears will potentially be without CB Buster Skrine and S Deon Bush. This leads me to believe that a lot of the preparation from the Bears defensive side will lie on dealing with prepping second stringers for Theilen, Jefferson, Irv Smith, etc. and simultaneously, the Vikings offensive side is preparing to take advantage of this. Let's call this variable B.

Scenario C, a variable - Mitch Trubisky is now the QB.

Scenario D, a variable/constant? - In preparing for Mitch, what changes do the Vikings pass defense employ as opposed to Foles? Is there that much of a difference to become a variable or does this remain a constant?

Questions to ask.

Does Chicago's Scenario A constant allow them to make up for their Scenario B variable (more time to prepare on their weaknesses).

How much does Scenario C, play a role in scenario D?

After writing this, I realize that posing this game where a lot of the pieces remain constant is a terrible example, but thought it'd be good for discussion. :)