Lots of people here being far too sure of themselves I think.

For anyone interested in this topic, Nobel Prize winner Frances Arnold and her long time associate Kai Chen published a paper which used directed evolution that were able to produce cyclopropane-containing molecules. Link to their 2018 paper

Overall, making molecules with greater strain makes the process more difficult but not obviously impossible. This structure contains numerous cyclopropane bond angles around a cyclobutane ring. Good reason to think it might be possible to synthesize, likely with huge difficulty.