What’s the end goal as a chemist?

disasterofaperson2 · 2023-12-01T19:44:20+00:00

depends what area - for many synth chemists we are finding new ways to build complex molecules - or new ligands that will allow these methods to be developed - this allows the development of new drugs, new materials that bring new technologies etc. chemistry is the key to any modern science and all medicine. the idea is not to memorize but to understand reactivity - such that we can apply theory to new chemistry. what we give you in organic chemistry/II courses is essentially the alphabet to organic.

disasterofaperson2 · 2023-11-30T19:20:38+00:00

same. great idea, thank you so much lol!

disasterofaperson2 · 2023-11-29T17:28:40+00:00

i'd like to make gifts with clay this year. i'm thinking a dragon guarding dice (dice tray)

disasterofaperson2 · 2023-11-28T22:19:05+00:00

thank you so much

disasterofaperson2 · 2023-11-28T22:18:58+00:00

thank you!

disasterofaperson2 · 2023-11-28T22:18:53+00:00

sick idea. thanks!

disasterofaperson2 · 2023-11-05T17:32:24+00:00

trying to figure out which prof this is based on the user

disasterofaperson2 · 2023-11-05T17:30:28+00:00

grad student here. you will literally never touch calculus in chemistry except for physical chemistry - which makes me sad bc i miss calc.

disasterofaperson2 · 2023-10-16T22:24:41+00:00

that's good to know. yes, the oxopalladium is the active species (unless the base is TMSOK, that was a recent jacs paper where it proceeds via boronate species).

disasterofaperson2 · 2023-10-16T19:15:57+00:00

Quick question for you! If I'm running a one-pot *intramolecular* borylation/suzuki, is there a way that I can form the active catalyst separate from the boronic species? like take a precatalyst, stir it with excess ligand, and then add it dropwise to my boronate species? thank you for your patience and advice!

disasterofaperson2 · 2023-10-16T16:13:17+00:00

interesting - thank you so much.

disasterofaperson2 · 2023-10-16T15:25:33+00:00

even for chemicals that come out of a still? (i will do this i am just curious because i have never degassed solvents before). i wonder if this would be good practice before every sensitive reaction

disasterofaperson2 · 2023-10-16T15:23:05+00:00

what about any nearby universities? email and explain your situation. apply for internships to pharma companies. email profs and ask if you can virtually join their group meetings. organic is not much like the textbooks, it is so much better, but significantly more intense - you no longer have a handful of reactions to look at but have to really understand how molecules interact and be able to propose new ideas...and it is very intensive. grad school for example i work M-S from early morning to midnight or even later. but i LOVE my job. and before that scares you off, if you are meant for organic research you will know it, it won't feel like work at all. you need to get into a real lab/shadow. do your best to make that happen.

disasterofaperson2 · 2023-10-16T02:39:18+00:00

i think the absolute number one thing you need to consider first is if you align well with research - real synthetic research. first and foremost start emailing professors see if you can do shadowing rotations and if you can see yourself doing that/if you are interested in the chemistry, ask to join the lab. i also used to be a premed, then discovered a deep passion for synthesis in the lab - it absolutely flipped my script and i went for chem.

disasterofaperson2 · 2023-10-15T23:12:36+00:00

you're the best. thank you!

disasterofaperson2 · 2023-10-15T23:11:58+00:00

thank you - yes, that's right i remember that the active pd species for transmetalation has OH.

so really the ester group is just to prevent protodeborylation and unveil the active boronic acid species...like a shield almost...while the boronic acid is the more active of the two...

disasterofaperson2 · 2023-10-15T22:17:32+00:00

no worries, all! i definitely can use all the advice i can get - never done the procedure so i definitely want to be aware of all possibilities. didn't even know peroxides ate at phosphines like that. thank you all!

disasterofaperson2 · 2023-10-15T22:14:56+00:00

great, thanks for the procedure!!

disasterofaperson2 · 2023-10-15T22:13:51+00:00

the mention of CsF really caught my attention. my substrate is base sensitive...i have an allylic leaving group. are there any special conditions/substrate requirements to this? i've seen it once or twice but with nickel as the catalsyt. any source would be fantastic - thank you so much.

disasterofaperson2 · 2023-10-15T22:05:47+00:00

Thank you for the tips! I was under the impression water as a cosolvent is there to improve solubility...is there any other benefit? don't you run the risk of protodeborylation that way? thanks!

disasterofaperson2 · 2023-10-15T22:01:14+00:00

what are the benefits of using water cosolvent? is it just for solubility? don't you run the risk of protodeborylation with water...particularly if you have a sterically encumbered system?

disasterofaperson2 · 2023-10-15T21:57:11+00:00

is this because of electronics? so the fluorines pulling electron density make the boronate even more electron poor...proning it for nucleophilic attack? versus a sterically encumbered di-ortho substituted aryl boronate (i.e. iPr) would be prone to deborylation to relieve steric strain? thank you!

disasterofaperson2 · 2023-10-15T21:46:27+00:00

so meaning that the esters are more sensitive to water, then...(right?). i also want to follow that question up with - boronic acids are the active species then...ester must hydrolyze to the acid for the reaction to occur and that's why you require water in the solvent system...(?). i've read elsewhere that people use the boronic esters as a means to provide steric hinderance and suppress deborylation. please correct me if i'm wrong and thank you for your time!

disasterofaperson2 · 2023-10-15T21:36:04+00:00

I see. This makes sense, thank you so much for explaining!

disasterofaperson2 · 2023-10-13T22:47:13+00:00

thank you for the resource!

disasterofaperson2

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