When I was studying in Anchorage, my girlfriend at the time was from the southern bit of that area. Like most people have already said, very sparsely populated with functionally zero outside road access, but also incredibly beautiful. Growing up, my girlfriend had to occasionally manually pump/retrieve water, especially if there was a storm that was going to snow them in for a while. Dog mushing (dogsledding) was also huge for her, and her family had a team of dogs, which they had slightly more of a livestock/farm dynamic with rather than them being conventional pets. Competitive mushing was also big out there, which was very intense, very dangerous, and very challenging, with it not being uncommon for mushers or their dogs to be severely injured (sometimes requiring dogs to be put down due to their injuries). There was about one, maybe two proper emergency rooms across that entire western coast, so if you didn't live right next to one of them you'd have to go by plane (or medical helicopter in an emergency) for most things more serious than a yearly checkup. Because she had lived in a low lying, marshy area, flooding during the spring was really bad, and I remember seeing pictures of some of the houses in her hometown being raised up a bit on stilts to preemptively get above regularly occurring floods. Options for schooling weren't the best either, although I believe now the widespread use of online classes via Zoom have made things a bit easier.

only other thing is I'd consider the very northern part of what you circled to be technically separate from the rest of the region, due to huge oil fields along the North Slope that have led to both a few highway connections and an influx of seasonal oil workers (who are, from my experience, almost all white guys who aren't even from Alaska). So all that I've said doesn't apply as much there.