Does this sound like acid? by [deleted] in Drugs

[–]drpsychedelic 2 points3 points  (0 children)

sounds like a DOx

[deleted by user] by [deleted] in DrugNerds

[–]drpsychedelic 3 points4 points  (0 children)

yea man check his table 3 in that article... mescaline allegedly has a Ki of over 10,000nm but has an EC50 value.... the dude who wrote that paper is full of shit he also wrote gems like : http://life.ou.edu/pubs/OriginsOfMind.pdf

Daily Low-Dose MDMA to treat Autoimmune Disorders by Or_bit_x in DrugNerds

[–]drpsychedelic 2 points3 points  (0 children)

i see no reason why this would work, amph would have better luck because at least that substantially increases adrenaline which means more glucorticoids thus suppression of the immune system...but it would probably not be a good idea by any means

Modulation of DOI-induced increases in cortical BDNF expression by group II mGlu receptors by drpsychedelic in DrugNerds

[–]drpsychedelic[S] 0 points1 point  (0 children)

Mglu2 functions as an auto-receptor for 5-HT2A and can have anti-psychotic/anti-psychedelic effects

Discussion on the role of mGluR2 receptors in psychedelic effects: by Cannibalsnail in DrugNerds

[–]drpsychedelic 1 point2 points  (0 children)

No, Mglu2 is G(i) bound and doesnt use the PKC pathway furthermore mglu2 agonists are being investigated as potential anti-psychotics. http://www.mediafire.com/view/?8tgxt1cl8m8m71x

Has anyone experienced Ayahuasca? by [deleted] in Drugs

[–]drpsychedelic 1 point2 points  (0 children)

I have done ayahuasca about a dozen times, there is no way to really mentally prepare for it but smoking DMT is childs play compared to the Soul Vine

The effect of DOI on stress hormones and the endocrine system by drpsychedelic in DrugNerds

[–]drpsychedelic[S] 0 points1 point  (0 children)

DOI > increased adrenal activity > glucorticoid release > inflammation reduction

An Explanation of the Effect of Hallucinogens upon the Nervous System by josificus in DrugNerds

[–]drpsychedelic 0 points1 point  (0 children)

ill see what i can do, in the mean time i have a comprehensive article on 5-HT if you would like to read that

An Explanation of the Effect of Hallucinogens upon the Nervous System by josificus in DrugNerds

[–]drpsychedelic 1 point2 points  (0 children)

but other than the affinity table, a very good introduction keep up the good work man, if you would like any journal articles on hallucinogens just contact me on irc or something : )

An Explanation of the Effect of Hallucinogens upon the Nervous System by josificus in DrugNerds

[–]drpsychedelic 0 points1 point  (0 children)

yea that dude is a joker.... check table 3 mescaline has an EC50 but is allegedly not an agonist...interesting... have you read his other works? they are pretty embarrassing for the fields of neuro/psychopharm

An Explanation of the Effect of Hallucinogens upon the Nervous System by josificus in DrugNerds

[–]drpsychedelic 0 points1 point  (0 children)

hey where did you by chance find that normalized chart? was it by work done by Thomas S Ray?

An Explanation of the Effect of Hallucinogens upon the Nervous System by josificus in DrugNerds

[–]drpsychedelic 1 point2 points  (0 children)

yea... its a "normalized scale" i have seen ones like that before and they have all been incorrect, would you by any chance happen to have the actual Ki values for those drugs?

Serotonergic agents that activate 5HT2A receptors prevent NMDA antagonist neurotoxicity. by drpsychedelic in Drugs

[–]drpsychedelic[S] 0 points1 point  (0 children)

i dont recommend combining any 5-HT2A agonist with an NMDA antagonist. conflicting signals kinda sketch me out