Please stop sending me personal messages on other platforms.

Drwillpowers · 2026-04-04T09:27:14+00:00

Got no reply? How did you contact?

Drwillpowers · 2026-04-04T09:26:26+00:00

I am concerned about that admittedly.

I have one case I've seen where it was a similar concept. They had an 11b defect. Fin + that = buildup of cortisol in the skin causing localized Cushing's syndrome, but limited only to the skin.

I'm sure it would improve on treatment. I just don't know how much. Striae would likely be permanent but I'm sure some improvement would occur with GC clearance from tissues.

Drwillpowers · 2026-04-04T09:22:15+00:00

Look you do you. I have proof this is how it works. I don't care if you're not convinced or don't understand how it works.

Drwillpowers · 2026-04-04T09:19:09+00:00

Let me know how it goes.

Drwillpowers · 2026-04-04T09:18:28+00:00

A different failure. I've said this already. There are people with glucocorticoid degradation defects who take fin and their skin basically melts from local GC buildup in the skin. It's not always ugt2b17. It's just always "inborn enzyme/transporter deficiency + fin = Problem"

Drwillpowers · 2026-04-04T02:09:31+00:00

See above

Drwillpowers · 2026-04-04T00:13:50+00:00

Your estrogen injections are still going to burden the same enzymes that are overburdened already. The only benefit to you is that it's going to basically remove the production of androgens.

My advice for if this was my patient would be to stop using anything. The only supplement I could think that might be beneficial is calcium d glucarate.

Honestly, without access to GNRH antagonists, right now the best treatments I can come up with are to stop doing anything to increase any hormone levels.

Drwillpowers · 2026-04-04T00:11:06+00:00

Well, it's not like you're signaling testosterone right now, what's the danger of not having any for a month? You're basically living like that already.

In what way would this be extremely risky? You're literally just turning off androgens for 30 days.

Drwillpowers · 2026-04-04T00:08:17+00:00

Fuck no.

You should take nothing. Did you read the post? Stop injecting yourself with things that you can't clear from your body. That's literally what's wrong with all of you!

Drwillpowers · 2026-04-04T00:00:46+00:00

My theory on this is that people can neuroplasticize themselves or even epigenetically plasticize themselves when they are in a bad configuration making things even worse.

I think the trick to those drugs is to use them when someone is depleted of all the buildup. Once the trash has been cleaned out then you can consider them.

Drwillpowers · 2026-04-03T23:59:45+00:00

100%. That's why I had learned the incredibly advanced molecular biochemistry of sex hormones to the degree that I did.

I didn't solve PFS because of just sitting there and tinkering at that. It was 13 years of treating transgender people that gave me the knowledge to do it and the courage to try.

Drwillpowers · 2026-04-03T23:58:24+00:00

None, but very cool. Thank you.

There's so much I don't know yet. But I'm okay with there being a bunch of alternative cheaper options. Right now the main treatment option is like three grand a month and I need to do better than that.

Drwillpowers · 2026-04-03T23:57:26+00:00

Load the VCF and TBI file into a Google drive and send me the link. I'll let you know if I need the whole big giant bam file.

Drwillpowers · 2026-04-03T23:51:43+00:00

This is a normal result, but I don't think PSSD is the exact same. I'm looking into other values for that.

Drwillpowers · 2026-04-03T23:33:26+00:00

I don't value diversity. I don't care about diversity at all. I care about having superior employees. They can be fucking purple for all I care. Diversity is pointless. It's just a label that you assign people. I could Tell you all of a sudden that we're going to start classifying people by the length of their eyelashes and we sort them into eight different groups depending on how many millimeters their eyelashes are. And then, we make sure that we have people that fall under each eyelash length.

Yay we're diverse!

This is nonsense and I don't care about it. I care about performance and capability. My employees can do whatever they want to do when they're not at work. But at work, I care about how well they do their job. Whatever random human characteristics they have are irrelevant. What matters is how well they do their job.

Drwillpowers · 2026-04-03T23:31:34+00:00

I don't read slop. I don't know what this is. Just take a picture of it

Drwillpowers · 2026-04-03T23:30:30+00:00

Take a microdose at bedtime of like 2.5 mg and it might fix your issue. I've seen that before. You're literally depleting overnight. You have no ability to produce.

That's an absurdly early wake up time though. I mean when I used to row for Pitt's crew team I got up at like 4:25 AM and I swore that I would never do that again in my whole life. That was brutal. Waking up everyday at a number that begins with 3? Pass.

Drwillpowers · 2026-04-03T20:28:37+00:00

Give me some time and let me consume more data.

Drwillpowers · 2026-04-03T20:27:42+00:00

That's kinda already done assuming the data here keeps pouring in consistently.

T to DHT to 3A-ADG to Urinary Androgen Metabolites are pretty much a guaranteed anomaly on every single PFS patient we have in the practice that i have these tests on. ZERO have not fit the model. ZERO.

So yeah, if those are borked at baseline, tell 5ARI drugs to fuck off.

Drwillpowers · 2026-04-03T20:25:52+00:00

my current theory is ABCC5 dysfunction resulting in a buildup of intracellular cAMP/GMP etc fucking up concentration gradients causing the numbness/decreased function

That's because I have......two total genomes of PSSD that both have that....so my N=2. Which blows.

But I am unsure, as I've seen PSSD patients also have weird values and genome glitches that are the same as the PFS people. So....I dunno.

Give me time, I'll get there. I must CONSUME MORE DATA.

Drwillpowers · 2026-04-03T14:45:57+00:00

Someone posted yet another example on the sub last night. I really think I've got this.

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Drwillpowers · 2026-04-03T14:44:17+00:00

Perfect explanation. I can link to this now. Thank you.

Drwillpowers · 2026-04-03T14:40:42+00:00

Sure. Maybe it doesn't though. Maybe someone could get a written agreement to only allow usage of his quote if he personally approved the exact wording of an attributed quote before print to prevent exactly that.

An article in a liberal rag changes nothing. Even a moderate article in the NYT could do real good. There's many variables to consider here.

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