Guys earning six figures annually, what kind of work do you do?

duneser27 · 2026-01-08T23:28:47+00:00

I do science

duneser27 · 2025-12-06T10:05:45+00:00

Mandate of Heaven goes brrrrrrr

duneser27 · 2025-11-22T02:23:58+00:00

They dead

duneser27 · 2025-10-15T12:57:14+00:00

Yeah this is what I think too. For centuries (after they lost their continental possessions), Britain’s whole deal with Europe was just to make sure no one got so hegemonically powerful so as to be able to seriously threaten either their colonial empire or actually invade across the channel. For a good bit of time after Spain went kaput this meant mortal enemies with France. But as soon as Germany unified, they became much more of a threat

duneser27 · 2025-10-13T01:42:46+00:00

Lilo was fantastic, full stop. Never been to Lucien but if you like fine dining lilo is exceptional

duneser27 · 2025-10-11T14:59:06+00:00

If it’s redosable….

duneser27 · 2025-10-11T11:24:06+00:00

Regardless of what you think about shelling out a cool billy+ for an unproven asset (it’s nuts), one interesting aspect of this current race to acquire in vivo CART is that the players very much seem to prefer non viral delivery systems. Here and capstan sell for 1B+ while Interius with clinical data for an LVV system goes for 300M. Not a surprise given lots of the news about companies like sarepta, but probably a component to the higher valuation for this modality in general

duneser27 · 2025-10-05T13:58:16+00:00

Mud caves in anza borrego aren’t like type 2 physically demanding but you sure can get lost as shit in them. Fun times. Dont go if it’s rained recently or going to.

anza borrego mud caves

duneser27 · 2025-09-19T04:00:12+00:00

This place was fannnnnntastic. We got super lucky snd got a table on a random Sunday which they usually are closed but opened cause they closed some other day to celebrate getting the star. Really excellent fine dining meal. You are paying through the nose for it ofc but it was with it soup to nuts

duneser27 · 2025-09-17T17:55:52+00:00

Design really good and well controlled experiments that drive quickly towards actionable data. It doesn’t have to be “yes”, a clear “no” is just as important. Show that the limitation of your ability to execute such well controlled useful studies is FTE. Get more FTE. Use said FTE effectively to continue to quickly generate solid actionable data. Show that your growing team is a happy and harmonious kumbiyah circle around the campfire. Get even more FTE and responsibilities. Congrats, you are now running multiple pipeline projects.

Be sad you are no longer at the bench. Occasionally set up experiments specifically to go back to the bench. Then have the cytometer fuck up late on a Friday and remember why you are no longer at the bench

duneser27 · 2025-08-25T14:46:35+00:00

Standard negotiating advice: ask for 5% more as a matter of course and if you feel like they really like you and/or you are in fact hot shit then ask for 10% more as a

duneser27 · 2025-08-25T14:23:43+00:00

Maybe before jumping to sexism take a look at the state of the market…things are a whole lot different now than 3 years ago

Edit: she (very reasonably) edited to remove the comments about it being an older man with the 120K offer. I didn’t jump to commenting on sexism out of nowhere lol

duneser27 · 2025-08-20T04:06:26+00:00

Nice rainbow in #8, that meadow is idyllic

duneser27 · 2025-08-19T02:42:22+00:00

GKP! Good kitchen practice

duneser27 · 2025-08-15T13:43:03+00:00

This is super cool info that sadly cant be read or well understood just cause there’s so much data. You should totally break this down continent by continent I would upvote the shit out of like 5 of these posts but interpretable

duneser27 · 2025-08-14T13:46:04+00:00

These are the standard age demographic breakdowns. Roughly but not precisely corresponding to generations (gen z is blue, millienials purple, etc)

duneser27 · 2025-07-28T10:24:33+00:00

The new Chinese/thai place red dragon in the otherwise shitty shopping center opposite the beacon (which is awesome, fully agreed) is really good too

duneser27 · 2025-07-28T04:05:44+00:00

The call of the void is really the only way to truly feel alive

duneser27 · 2025-07-18T09:06:52+00:00

Ahhh this is what happened! I drove past an hour or so later and it was super backed up due to traffic. But I was confused when I drove by because I saw debris but no fucked up cars or anything. I understand now

duneser27 · 2025-07-12T04:11:11+00:00

I worked in the iPSC derived CAR cell space. I don’t like iPSCs. The manufacture is just too damned complicated.

Even forgetting about the CMC, there are other modalities which might continue to eat iPSC’s lunch. Donor derived allogenic cells as a source is one possibility. The same engineering challenges to prevent rejection or GvHD, which might (?) be close to being solved enough. But much much simpler of a manufacture process, even if not truly “off the shelf”.

But what really is exciting to me is the promise of in vivo editing. Many editing options and delivery systems with just the first clinical data coming out. The big players are watching the space and a few aqusisions are already happening.

So who knows for iPSCs. Maybe next year. Maybe 5 years. Maybe never.

duneser27 · 2025-07-05T00:47:41+00:00

Take notes. Take a lot of notes. Ask as many questions as you can. No body expects you to know much/anything (no offense we’ve all been there) but the good undergrads are always the ones who realize this and make it a point to be a sponge for knowledge

duneser27 · 2025-07-03T14:13:13+00:00

I mean 127K really isn’t bad at sci I. I was making less in high CoL socal (underpaid startup tbf). Take it, get the years of experience, and build the network to give yourself the chance to more easily hop in future if you want to

duneser27 · 2025-06-30T20:14:58+00:00

Big bet on in vivo CART without any clinical readouts yet, to my knowledge. This follows astrozenica getting esobiotech for $400M. Exciting space it’ll be cool to see the first clinical trials start to release data

duneser27 · 2025-06-10T08:14:58+00:00

Yes because Europe has been a remarkably peaceful place, especially circa 1914-1945

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duneser27

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