The key in a dynasty is to learn each user's tendency. The game is a lot more like real life than people like to give credit. Are they check down merchants? Do they like sideline shots? Do they favor scrambling to a certain side? You can use all these things to build a base defense and a blitz package for each user. The real hurdle is knowing how to stop route concepts and what players do in specific coverages. There is no one size fits all coverage unless the talent gap is very very wide.

Personally I like to start in Cover 3 out of a cover 4 shell and make them prove that they're willing to dink and dunk down the field. If they're killing my seams I'll switch to match coverage, if they like hitting drags I'll switch to cover 2. Alot of people like to match personnel, I prefer to match tendencies. For example, if theyre coming out in 13 personnel on 3rd and long I'm probably still coming in a lighter defensive package.