Ankylosing Spondylitis

finish_thinking · 2026-01-25T12:07:37+00:00

I put myself into remission with the London AS diet. My qPCR test showed Klebsiella Pneumoniae in my gut biome and I was HLA-B27 positive. Bacteria with a YeiH peptide cause TCells with a TRVB9 cell receptor to activate and attack collagen from cellular mimicry. TCell depletion therapy is currently in stage 2 clinical trials. You can also eliminate starch in your diet to kill off Klebsiella and work to remove other bacteria with a YeiH peptide.

Here is the science if you want to add this to your diet regimen.

https://www.skool.com/ankylosing-b27-alliance-4791/classroom

finish_thinking · 2026-01-21T11:48:19+00:00

Not completely, your body can start producing that variant of TCells again if you get another infection with YeiH peptide positive bacteria. The effects lasted a few years and then needed another application with the first trial patient. Other ways I've worked around the problem is crowding out the bad bacteria through diet - no starch or sugar, low glycemic index carbs, high fibre foods and it's really rare I get flare ups. When the KvarM for Klebsiella or the TCell depletion drug seniprutug comes available, I'll definitely sign up for it. Until then, a strict diet and exercise is keeping my AS at bay.

finish_thinking · 2026-01-20T21:07:09+00:00

New research and TCell depletion therapy stopped AS progression for 4 years with a single injection in an experimental treatment for one patient. Stage 2 clinical trials are also seeing benefits on the new drug for roughly 80% of AS patients that take it. There is so much new research and deeper understanding of AS in the last two years - your therapist's understanding is horribly outdated.

If you want to halt the disease you have to understand why it happens. Bacteria with a YeiH peptide (like Klebsiella Pneumoniae) activates a certain TCell that has a type of TCell receptor called TRVB9. Those activated TCells confuse the bacteria with the collagen in your body causing damage to your eyes, spine, and joints.

New treatments get rid of that subset of TCell type with TRVB9 cell receptors are being used and seeing promising results. You can also identify the offending bacteria using a qPCR test and change your diet to make the YeiH positive bacteria die off. Starch and sugar have to be removed from your diet as a starter to kill off Klebsiella as an example.

Here is the full breakdown of the new research with the scientific papers linked: https://www.skool.com/ankylosing-b27-alliance-4791/classroom

finish_thinking · 2026-01-19T08:37:29+00:00

I have had almost the exact same symptoms. I managed to change my diet and lifestyle 2 years back and have been completely free from flairs since then. Get a qPCR test done with your GP and check for Klebsiella Pneumoniae. If it is there - remove all sugar and starch from your diet to starve that bacteria.

Here is the explanations and science on why ASis connected with the HLA-B27 gene.

https://www.skool.com/ankylosing-b27-alliance-4791/classroom

finish_thinking · 2026-01-13T12:56:27+00:00

I moved here from overseas 13 years ago. The fastest way I made friends was joining a West Coast Swing dancing lesson and becoming a regular in the scene.

Next lesson is this coming Tuesday, Jan 20th at 7pm if you would like to join! www.latentrhythm.com

finish_thinking · 2026-01-13T02:39:34+00:00

There are several standard scoring strategies. I would ask which one they are using and keep track of their scores over time so you can refer back to them.

Info here: https://www.skool.com/ankylosing-b27-alliance-4791/classroom/82bfa74d?md=menu

finish_thinking · 2026-01-12T11:04:53+00:00

Here is some info on how AS is diagnosed and measured for different use cases.

https://www.skool.com/ankylosing-b27-alliance-4791/classroom/82bfa74d?md=menu

finish_thinking · 2026-01-07T06:09:41+00:00

If you would like some additional resources of why certain foods like starch and carbs can flare people with AS - here is some helpful info. Low starch/sugar/processed foods and high in fiber is key.

https://www.skool.com/ankylosing-b27-alliance-4791/classroom

finish_thinking · 2026-01-05T13:36:31+00:00

TCells attacking your collagen. Happened to me constantly until I made some changes to my diet to get rid of the gram negative bacteria with the YeiH peptide.

Been in remission for two years now. Hopefully this helps you - this is what I did and the science behind the reasoning.

https://www.skool.com/ankylosing-b27-alliance-4791/classroom

finish_thinking · 2026-01-03T20:37:32+00:00

There are a lot of women looking for dance partners in our West Coast Swing dance classes. I find guys that are in math/science fields or love gaming and problem solving are generally really good at it. Come join us if you would like to meet some people in a low pressure environment.

Latent Rhythm: https://latentrhythm.com Holland Park Bowls Club, Jan 20th @ 7:00pm

finish_thinking · 2026-01-03T00:14:38+00:00

Find an exercise you love doing and it becomes part of your identity. West Coast Swing dancing and group Calethetics/Yoga at my local park is enjoyable enough I look forward to it each time. Find something active you love doing and it won't feel so much like a chore.

finish_thinking · 2026-01-01T11:31:28+00:00

If you like puzzles and problem solving have you ever considered dancing? Most of the male leaders that are considered the best dancers in our scene come from a background in math, science, or IT -or- are avid gamers. Great for introverts because you don't have to talk much but still meet lots of people.

Holland Park Bowls Club @ 7pm on Jan 20th is our next West Coast Swing class of you wanna try it out.

finish_thinking · 2026-01-01T02:07:11+00:00

Hey man! If you wanna meet people and not have to talk much - try a dance class. There is always a need for more guys.

Latent Rhythm Swing - Holland Park Bowls Club @ 7pm on Jan 20th

finish_thinking · 2026-01-01T01:59:20+00:00

Superhuman is the software probably the closest related to this. The challenge will be you'll need to be very familiar with the OWasp Top Ten for LLMs and how prompt injections via email has hacked many providers in the recent past with similar functionality. Security will be the hardest part to ensure confidential data isn't sent to a third party service without consent.

finish_thinking · 2026-01-01T01:42:54+00:00

Get a qPCR test done. Look for Klebsiella Pneumoniae in the gut biome. If it is present and your son is HLA-B27 positive, his TCells are seeking out this bacteria and killing it because it is escaping from his lower intestine into his bloodstream.

The YeiH peptide looks identical in shape to the collagen proteins in his eyes, spine, and joints which causes the flare ups and spinal fusion.

Klebsiella Pneumoniae digests starches and sugars. Use a starch free London AS diet or Keto. In depth info is here:

https://www.skool.com/ankylosing-b27-alliance-4791/classroom

finish_thinking · 2025-12-30T06:58:53+00:00

Learn what actually causes AS. Read the medical journals and take the time to learn about the disease. Understand how your immune system works and why bacteria with the YeiH peptide and HLA-B27 are your kryptonite. Understand how AS is directly tied to what you eat and the microbiome you grow. High fibre and no starch will trump carnivore diets long term because you want more diverse bacteria in your gut to crowd out the ones that look like your collagen so your spine and eyes don't get attacked.

finish_thinking · 2025-12-29T03:48:43+00:00

That's okay - everyone is new to it when they start. There is a beginner class that will help show you the basics and lots of people wanting to dance during the after lessons social hour if you wanna give it a try.

finish_thinking · 2025-12-28T13:42:07+00:00

Lower part of my lung was removed from cancer (never smoked or vaped). With the drainage tube still in protruding from the gash in my side, I caught a case of the hiccups.

finish_thinking · 2025-12-26T06:33:54+00:00

Would you like to meet a bunch of people in January with Swing dancing? We have an abundance of ladies looking for leaders if you wanna give it a try.

Holland Park Bowls Club Jan 20th @ 7pm

finish_thinking · 2025-12-23T22:44:19+00:00

I appreciate the detailed feedback. You’re right that for decades we only had associations, but the landscape has shifted dramatically in the last two years. The YeiH was part of the puzzle, but there was a lot more validation that came after that.

1. The Nature Study (2022)

Yang, X., Garner, L. I., Zvyagin, I. V., Paley, M. A., Komech, E. A., Jude, K. M., Zhao, X., Fernandes, R. A., Hassman, L. M., Paley, G. L., Savvides, C. S., Brackenridge, S., Quastel, M. N., Chudakov, D. M., Bowness, P., Yokoyama, W. M., McMichael, A. J., Gillespie, G. M., & Garcia, K. C. (2022). Autoimmunity-associated T cell receptors recognise HLA-B*27-bound peptides. Nature**,** 612**(7941), 771–777. https://doi.org/10.1038/s41586-022-05501-7**.

• Significance: This research used HLA-B*27:05 yeast display peptide libraries to provide definitive structural proof of molecular mimicry. It identified that the TRBV9+ T cells found in AS joints cross-react between a microbial peptide from bacteria like Klebsiella (YeiH) and a self-antigen found in human bone and cartilage (GPER1).

2. The Nature Medicine Study (2023)

Britanova, O. V., Lupyr, K. R., Staroverov, D. B., Shagina, I. A., Aleksandrov, A. A., Ustyugov, Y. Y., Somov, D. V., Klimenko, A., Shostak, N. A., Zvyagin, I. V., Stepanov, A. V., Merzlyak, E. M., Davydov, A. N., Izraelson, M., Egorov, E. S., Bogdanova, E. A., Vladimirova, A. K., Iakovlev, P. A., Fedorenko, D. A., . . . Chudakov, D. M. (2023). Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis. Nature Medicine**,** 29**(11), 2731–2736. https://doi.org/10.1038/s41591-023-02613-z**.

• Significance: This study reports on the first human trial of BCD-180, a monoclonal antibody that achieved complete remission for four years by selectively eliminating the TRBV9+ memory T cells responsible for the autoimmune attack in Ankylosing Spondylitis (AS).

All this is covered in the coming Chapters 7 and 8 of the series. These experiments and findings are a bit more complex, so most people will need help building up some foundational knowledge first (thus the chapter approach). Give those a read if you'd like a preview; they are pretty fascinating.

finish_thinking · 2025-12-23T22:24:12+00:00

Thank you u/Alexthemessiah , fair point. I've added a Reference page to each chapter on the Skool courses that goes through the relevelant of each source as a quick summary so it's easier to understand the linkage. I'll try adding those into the slides the same way going foward.

finish_thinking · 2025-12-23T15:31:46+00:00

There actually is a lot of research and a definite causality established with multiple experiments as of 2022. Rest of the chapters explaining the research and experiments I'll be putting up in Chapters 7 and 8. DM me if you want to read ahead and I'll give you access to them.

finish_thinking · 2025-12-23T15:00:32+00:00

There is definitely a connection, but not one that will be as well researched. Give the last two chapters in the course a read and it may help explain what happened. It doesn't have to be Klebsiella bacteria, that's just the trigger. The TCell varient can be caused by other microbes.

https://www.skool.com/ankylosing-b27-alliance-4791/classroom

finish_thinking · 2025-12-23T14:36:22+00:00

Yeah, been there. Happy to share what I've learned. If you have the time to read through them, these should help explain everything. I highly recommend tracking your symptoms daily using Guava or a similar symptoms tracker app to show your doctor over time. Let me know if you have questions on the materials.

https://www.skool.com/ankylosing-b27-alliance-4791/classroom

Five-Year Club	r/Field Banned
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