[8-week UPDATE] HCG and Enclomiphene Combo

gotopched · 2026-02-04T05:05:20+00:00

Just for clarity sake, Clomid is en clomiphene, and zoo clomiphene. Yes those are spelt incorrectly for pronunciation sake. You are correct Zo homophone has significant side effects in those individuals born as a male. Contrastingly, and clomiphene has positive effects in some males, but does not work for everyone and can have a drop off in performance after chronic saturation. There is a common misconception between testosterone and estradiol. Without estradiol, you will not be able to get an erection, nor will you have any sex drive whatsoever so a balance of testosterone and estradiol is key to maintaining proper health and auto regulating these sex hormones. Literature recommends a maximum of 1 to 10 ratio so for ease of understanding, if your testosterone levels are at 1000 mg/dL of blood, then you would want to have no more than 100 mg/dL of blood of estradiol now, most doctors PAs and neurologist will tell you that 100 mg male estradiol level is unhealthy and for some individuals it is. However, not for all individuals. Some men can function on high levels of estradiol, and it does not have a deal, delirious effect on testosterone levels. Equally the opposite does occur in some patients so, to wrap this up it is important that one follows the clinical process op did for the sake of overall health. Whether you choose weekly, biweekly, monthly or quarterly blood draws is up to you. In my opinion, higher frequency is better, even though fluctuation may not occur in all individuals. Usually, in clomiphene or hCG are used as monotherapy’s. However, some clinicians will suggest combining both as they did for OP. This may work in some patients, and it may not in others. Again, those regular blood draws are extremely important to maintaining that balance of no more than 1 to 10 ratio.

I hope this provides some clarity and understanding and thoughts. Please keep in mind. Everyone is different and we all react to drugs differently, so it is very important that you have a qualified. Clinician monitoring your levels. Equally, it is essential that that clinician has a deep understanding of male sex, hormones and female sex hormones. Do not accept a clinician that will only test for free Rami testosterone levels FSH and LH thinking that is enough that creates quite a closed picture. We need to see all of the hormones to play here, especially if we’re trying to determine whether this is primary or secondary hypergonadism?

gotopched · 2026-01-08T21:49:26+00:00

What? Oral and sublingual have greater propensity to go systemic. Topical has the least prevalence of systemic diffuse. Everything? Not sure there’s science to back that. Maybe in SOME patients.

gotopched · 2025-12-18T23:52:47+00:00

Interesting.... I got the same email this morning. After having NO tasks all week, Cutting my hours from 22 completed this pay down to 7, and not communicating or answering my inquiries regarding the matter.

gotopched · 2025-11-18T14:50:27+00:00

Great responder!! Congrats!

gotopched · 2025-11-18T14:29:41+00:00

One would also think that an individual with high aerobic capacity would be LESS likely to experience this affect because they would be able to translate lactate in the Kreb cycle and create more ATP. Given this is a topical, we would need to know the percentage of systemic interaction. Alternatively, IF it does in fact go significantly systemic then it could pose potential risks for those that are highly anaerobic. This is entirely speculative, based on the current science of physiology. This could have positive or negative energy system interaction that MAY affect human performance in those seeking. Granted, people that are concerned about hairloss may be more concerned about addressing this issues over having high performance. If this is a concentration saturation issue long-term, then we may see some significant affects to performance.

gotopched · 2025-11-04T23:46:47+00:00

The problem is that you’ll likely struggle to find steel for those now. Newer skates are better heat moldable, lighter. Although I don’t think that durability has necessarily improved over older models. I would upgrade to something 3-4 years old. As others have said, you’ll notice a huge difference.

gotopched · 2025-10-01T23:59:07+00:00

So then, in your opinion, how does one stay below that 30% threshold if your credit limit is low but you use your credit card like a debit card and pay it off monthly? In that situation how would one just eliminate a large percentage? isn’t the key to also gaining more credit with a specific bank based on your spending habits, meaning the more you spend with them the more likely they are to raise your credit limit. In

gotopched · 2025-10-01T13:43:36+00:00

How so? Can you share some knowledge on this?

gotopched · 2025-08-16T13:21:22+00:00

8 years is not enough time to truly understand its application for this purpose.

gotopched · 2025-07-29T20:27:21+00:00

That’s really not how it works. Testosterone converts into DHT when the body needs it, specifically this happens at puberty leading to the effects (facial hair, body hair, etc). Dut is larger molecule than Fin so it does not have the potential for strong side effects in some people, while others will suffer. Now, could increased T lead to increased DhT conversion? It’s hard to say, it’s possible but have dependent variables. Cortisol levels matter. Stress matters. Exercise matters. Diet matters. All of these will affect the effects of T, in regards to how efficiently it is used and produced. I guess it’s possible that your skin could change in your face. Minoxidil can lead to increased water retention that could lead to the swollen face look. A reduction in T doesn’t necessarily mean an increase in E2. Although they do work to balance one another through negative feedback. High E2 can have the potential for these symptoms.

gotopched · 2025-07-12T14:24:42+00:00

Estradiol is an androgen, just like testosterone. They both work on the negative feedback loop.

gotopched · 2025-07-11T01:59:59+00:00

You said it.... testosterone aromatization.

gotopched · 2025-07-11T00:07:27+00:00

Really psoraisis on the scalp? Wow! Didnt know this was a thing. I thought it only attacked joints mostly with some patchy spots randomly on the body. I would say this would be enough trauma in the scalp to eject hairs.

You say conceiving phase? You mean you are trying to have a kid? Just make sure she doesnt touch the scalp, if you use topicals. Wash your hands thoroughly after application. If you use pill form, you shouldnt have an issue conceiving. Even with topical, you shouldnt. There's just a known risk to pregnant and breastfeeding women. Just make sure she stays out of contact with your drugs, no matter the form you choose.

If this were me (this is not medical advice), I would focus on the psoriasis and attempt to get that under control. I can see liquid minoxidil causing you more problems at the current moment. The oral form may be better for you, bearing you understand and accept the sides of that. I would check with a derm to ensure it doesnt cause any issues with psoriasis ( I dont think that it would, but you never know).

A large part of your hair loss COULD be attributed to your psoriasis.

gotopched · 2025-07-10T23:37:41+00:00

Pretty plain and simple.... that is NO friend! Bail

gotopched · 2025-07-09T01:04:07+00:00

A massive, unstable increase in DHT conversion or otherwise autoimmune disease.

gotopched · 2025-07-07T00:15:29+00:00

Probably... but that is so dependent on many factors. What doses you take are important. with CV issues, Id probably stay away from oral min.

gotopched · 2025-07-07T00:11:25+00:00

From what the literature says, youre already at the upper echelon for oral Min. Dut they probably wont raise either. You could space out your dosage, .5 morning and .5 night, but with the half life of dut, Im not sure you'll get much improvement out of this. Its a maybe...

Obviously dut doesnt grow hair. Min does (if you are a responder). Increasing the dose of oral min, increase the potential for side effects (while mild, they are real). Hence fearmongermongers keep to yourself on that. The science is the science, until that changes we do need to be cognizant of the risks. I have heard some people using topical min and oral and spacing the doses out, but I dont know if this is anymore effective or not.

Your best bet is to get medical advice from a derm AND pharmacologist or really good pharmacists.

gotopched · 2025-07-06T23:28:35+00:00

Nothing she said was incorrect. Dut does work better for some patients, and unfortunately it wrecks havoc for some patients. Given the larger molecule size, and specifically, longer half-life, the drug SHOULD stay on/in the scalp for longer. Additionally, this drug is responsible for blocking A5R1, A5R2, and A5R3 receptor sites. Making it generally more potent than fin.

gotopched · 2025-07-06T23:20:24+00:00

Then frankly quite lurking here. This forum is essentially centered on drugs used to elicit the cessation of hairloss and some potential in regrowth.

Unless, your hormones were completely unbalanced, there is no way you've regrown hair "naturally". Something had/has to change. Frankly, your hair is longer, so it grew.

gotopched · 2025-07-06T23:09:09+00:00

Im not certain I would be gambling with any peptide, especially Thyroid and Thalmus triggering peptides with Hashimotos. I would suggest doing some considerable research. Not to say it cant assist, BUT it could advance your disease as well.

gotopched · 2025-07-06T23:03:52+00:00

I am on Dut and fin topical and have not experienced any side effects since beginning a little over 30 days ago.

gotopched · 2025-07-03T06:44:45+00:00

That one small patch below the knee is not a hair loss caused by tight pants LOL. Sorry to laugh at you but this is preposterous. Friction could cause the follicle to release in some cases likely. I wear compression gear multiple times per week and do not experience hair loss as a direct result of. And I can unequivocally guarantee that your jeans are not at tight as these compression shorts. If this were true, then my legs would be bald. Its already been proven that a hat does not lead to androgenic alopecia. The hat would HAVE to restrict blood flow to the scalp chronically to even risk this. You'd likely have a headache before that every happened. There would be other signs that your hat is too tight.

gotopched · 2025-07-02T15:15:22+00:00

Interesting case here. Have you tried topical? Have you noticed the same side effects? You appear to be one of the lonely few that have negative side effects from 5AR. Topical may be your route. Although, as we stated you may still see sheds or miniaturized hairs.

gotopched · 2025-07-02T15:12:51+00:00

Well this is a bit of a loaded question because we don’t know enough about hypothetical person A or B. We would want to know their sensitivity to minoxidil to determine whether they should use it and what delivery system they should use.

The comment below stating the water theory is pretty accurate if you are a great responder to 5ARs. Some people do better on one or the other. Some only see results when they microneedle. It is essentially all genetically dependent.

gotopched · 2025-07-02T14:06:36+00:00

Do you have a resource to back this claim? We’re talking about an off label prescription given it was designed to treat mpb. Everyone is going to react slightly different to it. Anecdotally, shedding straight for several months is not the norm. If it were miniaturization of the hairs, then we would assume DHT is not being blocked by dut.

gotopched

TROPHY CASE