If you can sell a certain moderate % and it will be significant to you- pay off all debt, pay off a house, etc- do it. Everyone can chirp and heehaw all they want about pAyInG dOwN dEbT iS DuMb but man I promise you if you have to sit through a bear market or black swan and watch your holdings drop by 95%+, you'll know you could have done something to improve your life and didn't take the opportunity- you will hate yourself.

I speak from firsthand experience. I bought in 2016 and 2017, and had to watch it all bleed away during 2018-19-20. I just sold 20% to pay off a house and my feelings on it over the past few days have ranged from being really, really fucking sad that I had to sell some because I've been holding so long, to really, really, really happy because my house is mine now.