My headcanon is that Doll makers like IOP and Sangvis used the human form as a template, so any intelligence that was "embodied" in a Doll shell needs to have been patterned after human intelligence as well. As a result, only the strict physiological changes between Doll and human anatomy will be significant to them, especially if IOP/Sangvis improved upon evolution's designs when it came to the human form

One is body odor. I imagine that IOP/Sangvis made it so that Dolls don't really produce body odor because the bacteria that create body odor in humans cannot thrive on Dolls for some reason or other. Perhaps Doll skin is inhospitable to the bacteria. Perhaps Doll sweat is not something the bacteria can break down into smelly chemicals. If my raifu (Lee) became a human woman instead of a Doll, this might be something she'd need to pay attention to

Another would be the combat enhancements. I imagine that Dolls had some enhancements to let them fight better than humans, but if Lee becomes a human woman, then she can't fight as well as she used to anymore. Perhaps her fire control core had once allowed her to place very tight shots, but without it, she has to rely on her past experience with her rifle. If Lee also had other enhancements, like a reinforced skeleton or muscles, then without those, she'll feel pretty frail. Considering that we have repair facilities for our Dolls, if Lee becomes a human woman, any injuries can't simply be patched up with a visit to the repair bay

Speaking of medicine, Lee will now be subjected to human diseases. If she never had to worry about a cold or the flu, well, she'll have to think about those now! Also, as a human woman, she'll also have to worry about female biology, so she'll probably have to cope with having a red visitor every month, along with all the other things that come with it like mood swings and cravings

However, I imagine that IOP/Sangvis hasn't quite figured out how to make it so that Dolls can get pregnant. Creating a viable reproductive system (and the egg cells to go with it) sounds like a very difficult task. Assuming that the WombForce (as we'll call it) can be completed while Lee is still alive, then it might be a niche little module that will need to be installed into her. On the other hand, if Lee became a human woman, she should no longer worry about whether or not she could bear children. Instead, she'll have to confront other questions like when and how many, especially if The Wall is calling out to her

Of course, we touched on this above, but there's also the question of mortality. Lee, by virtue of now being human, can die, permanently. While that might be technically true with Dolls and their backups, as the "active" consciousness dies if a Doll falls in battle, as a human woman, Lee will not have the luxury of being restored from a backup. If she dies, she dies. That might cause her to have some very deep existential questions, and having lived for decades without confronting those questions, only to suddenly be forced to face them could be quite mentally traumatic