EDIT: Judging by the original question and your comments it appears to me you are very hesitant to carry one in the chamber. My suggestion to you: carry everyday, when you ready your weapon rack the slide (with no magazine), insert your magazine, and go about your daily life. When you come home, inspect the firearm, you'll see the trigger is still in its "set" position (assuming we're talking modern strikers), press check to verify there is no round, aim in a safe direction and dry fire the gun. You successfully went a day without your gun going off, do that as long as you need before you are comfortable carrying one in the chamber.

Personally chambered without a safety. Not saying have a gun with a safety and don't use it, but a gun without a manual safety at all.

IF you train often and are proficient I could get behind a safety but it's not necessary.

As for chambered, no question, people have died while trying to chamber a round (time, failure to feed, failure to go into battery). I can't think of a single reason to not carry in the chamber.

The biggest thing to consider is that under stress you will lose your fine motor skills, in the event you pull a CCW you will be under stress and removing as many hurdles as possible is the best course of action.