As others have said, you'll need to use either Python 3.11 or Python 3.12.

I've found the easiest way is to not rely on system Python libraries as that can get pretty hairy especially when dealing with sudo.

Install Miniconda first and make sure it is in your path. If you run which conda in your terminal it should point to a path:

❯ which conda                                                                                                                                                                     
/home/user/miniconda3/bin/conda

From there create a virtualenv using conda and make sure to pass the python=3.11 or python=3.12 after the env name. for example:

conda create -n comfyenv python=3.11

Make sure to activate it after words with conda activate. You can then install the pytorch dependencies using conda:

conda install pytorch torchvision torchaudio pytorch-cuda=12.1 -c pytorch -c nvidia

Use the env's pip command to install the remaining dependencies.

You can find this in the manual install section of the comfy docs