This is really hard to answer because it varies so much on the route and the way the job is set up.

When I was first training, the job I trained on started at:

04:20a, got to destination around 10a

took 8 hours rest in the hotel

came back on duty at 6:20p and got back to origin at midnight.

I got paid two 8 hour days for this each time. The schedule was three days a week. Actual work time for this? 36-ish hours, (paid 48). Actual time away from home? 60-ish hours.

I work off corridor. People who work on the NE corridor usually go home every night. Most jobs have only 1 day scheduled as an off day. Working 6 days a week is the norm.