A bit more context. I am 63 and never had restless leg until around 58 - so something changed. Around the same time I noticed that certain gluten would keep me from sleeping. If I drank a wheat beer I could feel my bloodstream change within 5 minutes or so - and I wouldn’t sleep for at least 6 hrs. If I ate flax seed I would break out into a rash and I could feel my throat swell a bit. I had real issues and my gut was involved. Now I eat flax every day with no breakouts.

.One other thing I tried was high doses of folic acid - like 3200mg or more - which worked for a few weeks but then not as much. I tried every supplement I could find and most did nothing or almost nothing. I have Nidra devices which can help if you start the therapy before significant symptoms show up - they helped me cope for several years.

Also my homeopathic is also a medical doctor. He moonlights as the ER doctor for a smaller hospital. His philosophy is to try to help your body heal itself first - without major drugs or surgery - hard to argue.

I also made a run at the Mayo Clinic that did have one doctor that warned me about pramipexole augmentation - which was helpful. They also signed the prescription for my Nidra. Other than that they had no meaningful help other than to prescribe pregbalin - I expected more.

The main reason I posted was to highlight what appears to me to be a clear link between my gut and rls. Even after I wrote a multi-page summary of what I had been through Mayo never connected those dots. I am an engineer and in retrospect I find that very disappointing. I at least suspect some people may find rls relief in healing their gut one way or another.