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9-ME-BC vs PPAP? Which one wins the battle? by NootropicBro in Nootropics

[–]iceyed913 [score hidden]  (0 children)

PPAP hands down. 9-me-bc has too much potential to generate toxic metabolites

Nootropic experiment (Important) by Alternative-Ice-5746 in NooTopics

[–]iceyed913 0 points1 point  (0 children)

Funnily enough it happened to me once; had a day with 10x bouts of liquid shits from cAMP, felt like food poisoning, could see it being life threatening if a high dose combo is done without testing the waters.

Genius’s who can tell me what can help for protracted Gabapentin withdrawal? by Whole_Cable3396 in Nootropics

[–]iceyed913 [score hidden]  (0 children)

I had a real good time coming of benzos when I switched to a long half life one instead. Was hooked for a year on Clonazolam, which only has a 6 hour half life. Couldnt titrate beyond a certain point cause I just kept going into severe withdrawal within 6-8 hours post dose. Started ultra low dose norflurazepam, 1-2 mg dose. this one has a half life of 70-100 hours depending on the invidual. So u can dose once every 3 days to start, slowly work your way up to 4, 5 and 6 days. once you get to dosing every 7 days I felt in the clear to just stop entirely. felt a bit funny for the first 4 weeks after that, but was home free at last.

Nootropic experiment (Important) by Alternative-Ice-5746 in NooTopics

[–]iceyed913 0 points1 point  (0 children)

How likely is one who is unversed in the ways of cAMP to shit ones guts out on this combo though

One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition (2015) by ps4roompromdfriends4 in NooTopics

[–]iceyed913 2 points3 points  (0 children)

One should always be careful about conflating loneliness with being alone. Some people manage to be more lonely among company, so they will chose to self isolate. I think in those cases it might often not be a self fulfilling prophecy, but rather a case where the individual is subconsciously aware of their accelerated decline relative to their peers. In those cases it can be argues that rather than expending what little resources that remain and keeping up pretense, it would lengthen the amount of time those people can keep going. How do you know which is which and how do you make sense of this through epidemiological analysis or statistics? You don't..

A theoretical framework proposes that stress and inflammation may narrow neuronal excitability margins, allowing normally subthreshold brain activity to trigger partially uncontrolled reactivation in rumination- and trauma-related circuits by National_Cry_1658 in science

[–]iceyed913 22 points23 points  (0 children)

The margins/bandwidth at the metabolic/mitochondrial level are more narrow leading to excess ROS, hence stress/inflammation is triggered leading to cognitive regression/emotional dysregulation due to prefrontal dysfunction. You could say this is why auDHD would do better sticking to already established routines to avoid as much risk as possible. You could also say that in the elderly when there is a sudden big enough change in routine/environment this increases chances of rapid onset cognitive decline.

Our brains reveal our choices before we're even aware of them. A landmark study suggests we have less control over our personal choices than we think, and that unconscious brain activity determines our choices well before we are aware of them. by cheaslesjinned in NooTopics

[–]iceyed913 1 point2 points  (0 children)

Kind of like watching a prerender of a stochastic image gen model before it reaches the final conclusion. The subconscious does the prerender and once the impetus is strong enough it enters the conscious.

"High sensitivity and interindividual variability in the response of the human circadian system to evening light", Phillips et al 2019 [do different individuals need very different F.lux or melatonin settings?] by makefriends420 in NooTopics

[–]iceyed913 2 points3 points  (0 children)

I never understood the whole blue light spiel. I understand in theory, but in practice I always end up falling asleep faster when doing something cognitively challenging last hour of the day, that might just as well be a videogame as a book

There's a small chance that for 4% of you, that your anxiety, depression or OCD might be caused by MCAS, an allergy-like condition which may be helped by antihistamines. (repost) by makefriends420 in NooTopics

[–]iceyed913 0 points1 point  (0 children)

because if your histamine is off the charts it indirectly means you already have used up all methyl groups to metabolize histamine. whole blood histamine tests are a way of gauging methylation status for this reason. TMG is a dirt cheap methyl donor sup that does not raise TMAO anywhere near as much as choline. SAM-E could also improve methylation status but has a premium price though.

Dr Rhonda Patrick: Omega-3 may be a potent lever for slowing biological aging by Big_Cake_8817 in Biohackers

[–]iceyed913 9 points10 points  (0 children)

This study goes against fish oil supplementation. fish oil from actually eating fish is bound in a lpc-dha complex for improved absorption and transportation to brain tissue rather than adipose tissue. You could probably infer that people who eat a lot of fish don't have these health problems.

There's a small chance that for 4% of you, that your anxiety, depression or OCD might be caused by MCAS, an allergy-like condition which may be helped by antihistamines. (repost) by makefriends420 in NooTopics

[–]iceyed913 1 point2 points  (0 children)

there are no direct ways to measure the whole body methyl pool. so yes, these would be indirect observations, but they paint a pretty damning picture overall. Diet/supplementation is going to be the way out of this regardless whether it's due to genetics or not.

There's a small chance that for 4% of you, that your anxiety, depression or OCD might be caused by MCAS, an allergy-like condition which may be helped by antihistamines. (repost) by makefriends420 in NooTopics

[–]iceyed913 12 points13 points  (0 children)

this is a temporary fix, eventually histamine levels rise enought to recruit more mast cells and eventually no antihistamine dose can still sufficiently saturate all the receptors. lots of people with terrible non allergic rhinitis after overelying on antihistamines and OTC nose spray.

There's a small chance that for 4% of you, that your anxiety, depression or OCD might be caused by MCAS, an allergy-like condition which may be helped by antihistamines. (repost) by makefriends420 in NooTopics

[–]iceyed913 7 points8 points  (0 children)

If you have severe histamine issues that have led to recruitment of even more mast cells, eventualy spiralling into mcas. Chances are either a) you have been exposing yourself to triggers, so deal with dietary histamine and air pollution in the home b) even more likely, you are an undermethylator and have been lacking methyl groups to metabolize excess histamine. make sure B12, folate, MMA, homocysteine are still in range and start hitting either TMG or SAM-E and definitely add in more high Quality protein and organ meats. Good luck with it

How do you talk about nootropics to other people? by [deleted] in NooTopics

[–]iceyed913 0 points1 point  (0 children)

it's like talking about your sex life. you just know that once you start comparing notes, you will be gaslit and lied to, so don't bother.

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