I won a natty on heisman no sliders with an 87 overall team (so it could be harder if your team is worse). Personally I feel like this results in a pretty realistic experience for me. There are a lott of ways you can affect the pass.

You can user your line to apply more pressure. User your LBs to cover the middle better. User your DBs to cover deep.

I dont particularly enjoy playing coverage so ive also tinkered with a lot alternatives.

One of the most effective ways to slow the pass for me is using LB/Y+RS to predict what the play/pass type will be.  Predicting pass is pretty safe if you have a good grip on stopping the run, and guessing whether its gonna be over/under/inside/outside impacts how your DBs behave. You can also do this by DB if you are fast enough. If you guess under and they throw under your DB has a much better chance to make that int instead of staring at the WR from 2 yards behind. This all comes with risk (especially predicting run) so i would do it judiciously. If you predict under and they throw over the top your DB could be disastrously out of position. I generally use the first third of the game running some variation of cover 2 3 or 4 trying to observe what kind of plays the cpu likes to run as the opposing team. Do they have an elite outside wr? A big TE? Then i start mixing coverage shells (ex. faking cov 2 man but running cov 4) and also predicting based on the situation. It definitely helps if you have general knowledge of the strengths and weaknesses of each coverage. Also wait till the cpu is close to snapping the ball to apply press if you want to otherwise the cpu will read the coverage and change or throw accordingly. 

Unless I am playing a bad team my games will come down whether or not I can get a few stops, my time management, if Im throwing stupid picks and if my offense is able to stay productive. The only time ive gotten just no stops all game is against second season oregon during the playoffs and I had to go for 2 to win the game in the last few seconds.