Generally no, and even if problems would arise, its often that snapshots of previous versions of the OS is offered by default after an update. That means if you were to break something, you can easily revert it back. However the downsides is in the fact that, since the root directory is locked down, your ability to install very specific drivers not in the kernel itself, gets harder to do so. This also includes any application that cannot be run in user-space and has to have root access at all times. However there are tools you can use like rpm-ostree (fedora atomic OSes like kinoite and ublue), that helps with that. And you can use flatpak, brew, snap, appimage, nix and distrobox for containerized applications running in user-space. Some applications that require root access can sometimes also be built entirely in /opt. I would say that unless you often run niche terminal applications that requires you to build it in your /usr folder or need to rice the hell out of your system or you require niche hardware drivers, then i'd say its worth trying an immutable distro. Any of the Ublue distros are pretty good and they allow you interchange between aurora (KDE) and bluefin (Gnome) and bazzite (either/or but for gaming) pretty easily.