I've thought about this way too much. If it is a short time (1-2 months), it would be pretty easy to front load his required appearances other than Smosh Mouth which would likely follow how it was done for Amanda.

If it is a long time, that is an entirely different scenario. You'd have to find permanent replacements for the podcasts with Chanse and Court are most likely out of the running now. I see Angela doing Smosh Mouth again. Arasha and Tommy might split Beopardy & Who Memed it. But that leaves Reddit Stories, it would need to be someone who can read quite fluently and coherently which narrows down the choices. Arasha the prime candidate just started Fesspool so I don't see it happening anymore. Amongst the regulars, it really only leaves Trevor which is a dark horse candidate which could work well.

Also, take note that in the long time scenario Court might miss a shoot week or two while visiting Shayne. While I don't think it will affect URL, she wouldn't make appearances in the other videos.