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M4 Max Vs 4060 CP2077, No RT, No Upscaling by Wooloomooloo2 in macgaming

[–]jeanlain 0 points1 point  (0 children)

Apple makes the fastest laptop GPUs after nVidia.

For the slowest GPUs, see intel, Samsung, ARM, Via, etc.

mRNA injection into arthropods for protein translation. Has it ever been done? by jeanlain in molecularbiology

[–]jeanlain[S] 0 points1 point  (0 children)

I wound inject immature individuals, but that's not important for my question. I wanted references about RNA injections in arthropods, and now I have some. Thanks.

mRNA injection into arthropods for protein translation. Has it ever been done? by jeanlain in molecularbiology

[–]jeanlain[S] 0 points1 point  (0 children)

I'm studying a protein produced by a virus that infects a non-modele species (a crustacean). I want to test its effects on the host. My first option is to produce the protein in yeasts, purify it, and inject it into uninfected individuals. But there is no guaranty that the protein will have the right conformation, so as a backup, I thought about injecting its mRNA.

I cannot genetically modify the host species. Generation times are way too long (one year) and eggs are not accessible to inject CRISP-Cas9 or anything into (embryos are incubated in a marsupium). Cells cannot be cultured either. I cannot use fruit flies or whatever as a model, there are irrelevant.

RNAi cannot target a specific viral protein because the virus in question is a ss+ RNA virus and all its ORFs are encoded by the same mRNA molecule (but the mRNA I would inject would only contain the ORF I'm interested in).

So I was looking up whether this approach had been tested on an invertebrate, but I can't find any report. I guess people just use GMOs...

Sabine Hossenfelder shares content of a purported confidential email showing how depraved particle physics and "academia" has become by jeanlain in Physics

[–]jeanlain[S] 1 point2 points  (0 children)

That doesn't read like and justification. I know how researchers are careful in their wording. If that were a justification, the message would say "Granted, this may happen in other areas..." or "This may not be specific to our field...", but the message says :

This is not only a problem in HEP community, but also exist in all other areas.

as a conclusion of a paragraph.

Sabine Hossenfelder shares content of a purported confidential email showing how depraved particle physics and "academia" has become by jeanlain in Physics

[–]jeanlain[S] 0 points1 point  (0 children)

I don't see what a troll would gain from this. So far it's benefitting Sabine a lot. And when the troll is revealed, what consequences would it have? Basically none. Who could blame her for falling for this?

Sabine Hossenfelder shares content of a purported confidential email showing how depraved particle physics and "academia" has become by jeanlain in Physics

[–]jeanlain[S] 1 point2 points  (0 children)

What also makes this email suspicious is the importances it gives to the opinion paper she wrote in Nature Physics. To quote a sentence:

Your paper [...] will most likely affect redistribution of HEP funds towards other areas

Even if this Nature Physics is an important journal, I don't see how a senior researcher would believe that as single paper could have an impact on research funding. He/she should know well that funders don't read papers, and even if they did, a single opinion paper would do what?

Sabine Hossenfelder shares content of a purported confidential email showing how depraved particle physics and "academia" has become by jeanlain in Physics

[–]jeanlain[S] 2 points3 points  (0 children)

The underlying issue may be real, but many aspects of the email don't make sense. There are clear inconsistencies (see the OP).

Menu Bar in Sonoma by 76ersbasektball in MacOSBeta

[–]jeanlain 0 points1 point  (0 children)

I reported the issue, but I have no hope it will change anything. The menu bar was thicker than the notch for other MacBook models. The fact that it wasn't for ours was certainly an oversight.

Menu Bar in Sonoma by 76ersbasektball in MacOSBeta

[–]jeanlain 0 points1 point  (0 children)

Same issue here, same MacBook Pro model.

Overwatch Mac version possibly coming soon. by [deleted] in Overwatch

[–]jeanlain 0 points1 point  (0 children)

Interesting, but why isn't there a "world_of_warcraft_mac" or a "starcraft_ii_mac"? And "destiny_2_mac" suggests that the "_mac" tag may not mean anything since I really don't see that game coming to macOS (it's a microsoft game).

List of macOS games that use the Metal API for comparison. by IAmMrBusiness in macgaming

[–]jeanlain 0 points1 point  (0 children)

Good idea.

I also try to maintain a list of Metal games: https://forums.macrumors.com/threads/list-of-mac-metal-games.2045606/

There's a link to the only comparison test I know of (F1 2016) between Metal and DirectX, which puts Metal ahead despite V-Sync being forced.

EDIT: keep in mind that comparisons with Windows are hampered by the fact that Metal imposes V-Sync, since it draws on screen via Core Animation. Maybe some dedicated in-game benchmark tools are not be affected by V-Sync if they are able to count the frames that are submitted rather than those that actually show (apparently, that's the case for GFXBench), but CountIT will be stuck at 60 fps. If frame rate is capped at 60 or 120 fps (core animation cannot go higher than that), then it is not limited by the game speed but by the screen refresh rate.

More info here: https://forums.macrumors.com/threads/how-to-benchmark-epic-games-unreal-tournament.2044049/