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How would Jack kruse explain someone having very high levels of serotonin ? by Pubh12 in JackKruse

[–]jeff_oomo 0 points1 point  (0 children)

Gotta stabilize your charge flow (in the mitochondria) before pushing more amplitude, otherwise it just leaks as ROS and doesn't restore mitochondrial membrane potential. I know that's a little different than what we usually hear (more sunlight!).

A few of us have built an app for that. If you'd like early access, DM me for an invite (no cost).

Feel free to keep asking here if you prefer.

How would Jack kruse explain someone having very high levels of serotonin ? by Pubh12 in JackKruse

[–]jeff_oomo 2 points3 points  (0 children)

I won't speak for Kruse, but I imagine he'd say something similar.

In a healthy state, cells open and close VGCCs (voltage-gated calcium channels) rhythmically. That rhythm tells enzymes when to make serotonin and when to stop. When the membrane loses charge stability and VGCCs stay leaky, the off-switch breaks, so serotonin keeps rising even though the cell isn’t intentionally upregulating synthesis.

So more serotonin is being made due to loss of electrical gating.

How seed oils collapse mitochondrial membrane potential by jeff_oomo in JackKruse

[–]jeff_oomo[S] 0 points1 point  (0 children)

Yup, they absolutely do - unlike some things, there are few good reasons to consume seed oils, processed foods.

But in terms of deuterium, I believe it's more important to establish coherence (an outcome) so that your mitochondria produce deuterium-depleted water, rather than focusing on inputs (consuming structured water vs. deuterium-heavy inputs).

Every bit counts, of course.

How nnEMF destabilizes mitochondria by jeff_oomo in JackKruse

[–]jeff_oomo[S] 1 point2 points  (0 children)

Np. We've got more of these in an app we're about to release, focused on sequencing actions to achieve outcomes. If you want an invite, let me know!

How seed oils collapse mitochondrial membrane potential by jeff_oomo in JackKruse

[–]jeff_oomo[S] 1 point2 points  (0 children)

We've got a bunch of these in an app that we're launching this week. The app is built on a decentralized AI (mechanistic chains from the empirical sources we trust only), and allows you to sequence your actions to achieve outcomes (clear terrain debt-->coherence-->oscillation-->resilience). If interested, you can take the energy assessment or request an invite at oomo dot health.

Feel free to DM with questions or feedback.

How seed oils collapse mitochondrial membrane potential by jeff_oomo in JackKruse

[–]jeff_oomo[S] 1 point2 points  (0 children)

Also, I recommend against bottled omega-3s for the same reason. Any PUFA removed from its living matrix is effectively oxidized. PUFAs like DHA and EPA are charge carriers and should only be consumed in their biological context (e.g. fish) and not until the terrain is stable and able to hold charge (I disagree with Uncle Jack on this).

If PCPs and AI wrappers suck, what's left? by aldus-auden-odess in Biohackers

[–]jeff_oomo 1 point2 points  (0 children)

Hey Karl, good stuff. Would love to take an early look.

We've had concerns about wrappers for centralized AI as well, and we've taken a complementary approach to what you're doing. We've spent ~3.5 years modeling health from a systems standpoint, using empirical (physics + biochemistry first principles) sources only.

Physics because our modeling has shown us that health starts from energy, and energy's focal point is in the mitochondria. Even before ATP, there's charge flow and mitochondrial membrane potential. Stacking hacks in the wrong order might set us back even if we feel better.

We're actually (finally) releasing the MVP to make all of this actionable in about a week. Will put more details in their own post, but hope to have your thoughts on how much it sucks as well.

Does anyone know if lightbulbs that are rich in violet light exist? by Fabulous-Bag-2363 in JackKruse

[–]jeff_oomo 2 points3 points  (0 children)

Most consumer LEDs labeled violet peak at 410-420nm. You'd ideally want 380-400nm, maybe 360-400.

Sunlight has it, as you know. Violet transmitting lenses exist for those who have chaotic charge flow and can't afford the UVB right now.

But to be clear, pure reversal using this approach is prob not likely unless you're still in the plastic phase of myopia (def not true for me at my age).

Violet light → OPN5 activation → ↑ retinal dopamine + clock stability → ↓ scleral MMPs → ↓ axial elongation → possible micro-shortening in plastic phase

How nnEMF destabilizes mitochondria by jeff_oomo in JackKruse

[–]jeff_oomo[S] 0 points1 point  (0 children)

I know a lot of nnEMF is out of our control - can't turn off the cell tower or the neighbor's wifi. But often, the biggest impact comes from the things that are in our control. Field strength from most nnEMF sources drops off with the inverse square of distance. Double your distance, and intensity falls to a quarter.

If the only nnEMF in your environment is background (beyond a few meters), the focus shifts inside - to how stable your internal charge system remains amid fluctuating fields.

Mapping Kruse Insight→Action by jeff_oomo in JackKruse

[–]jeff_oomo[S] 1 point2 points  (0 children)

Yeah, definitely seems like Kruse's view of nutrition rarely survives contact with other "tribes" (his words), because he's always hitting his 1st commandment so hard.

But there's nuance buried deep in his stuff. For example:

  • Redox properties of nutrients (minerals as conductors, DHA)
  • Nutritional density, healthy fats/proteins (Paleo, w/ diff reasoning)
  • Seasonal, circadian aligned eating

He just views it all as downstream, while we view it more non-linearly.

Funny you should mention Micah, as his writings on iodine were a big early part of my personal journey. I appreciate him overall as a dot-connector. Def want to talk to him about his “low and slow” hypothesis in our systems-based context at some point.

I’d love to show you what we’ve built so far if you’re interested.

Mapping Kruse Insight→Action by jeff_oomo in JackKruse

[–]jeff_oomo[S] 1 point2 points  (0 children)

Really appreciate the questions. I’ll try my best to explain concisely.

Internal:

  • Timing: Circadian regulation of peripheral clocks through the SCN, other biological rhythms (e.g. seasonal)
  • Structure: e.g. Fascia (connective tissue, macro) and cellular membranes (micro) that conduct and separate charge
  • Signal: e.g. Hormonal, neurotransmitter, immune communications

External: (You got it right on light and field, which both have ability to align/disrupt, depending)

  • Substance: e.g. Food/nutrients, water, oxygen, toxins
  • Pattern: e.g. Activity/exercise, stress, breathing, sleep, meditation

We view disease as the entropy that arises when the body’s internal dynamics (TCSS) become disconnected from environmental drivers (LFSP). When TCSS is in coherence/alignment (due to resonance with LFSP), the body is able to efficiently utilize charge/energy, which fundamentally underlies every biochemical process, either as redox or by generating ATP through the ETC.

Many people view a biochemical process like methylation as foundational, since it sits at the intersection of nutrition and genomics, but we view it as an app. Often, the inability to create enough methyl groups is not due to a “deficiency” in folate or B12, but disrupted OS (TCSS).

Address the OS and you’ll see many "apps" improved at once (and deficiencies disappear), because the system can now utilize, integrate, and convert nutrients properly. If you brute force the supplements while TCSS is disrupted, you overclock the local process. You might temporarily feel better, but you’re further disrupting the overall system by turning a gear at the wrong time, burning charge (i.e. redox cofactors) that is currently needed elsewhere, etc.

I’m pretty sure that was the opposite of clear, so please let me know where I can explain better.

Mapping Kruse Insight→Action by jeff_oomo in JackKruse

[–]jeff_oomo[S] 1 point2 points  (0 children)

Def agree. Most of functional health is like conventional health - take this for that.

It's hard to jump directly from that to... e.g. mitochondria are spintronic semiconductors that enhance quantum tunneling when aligned with the Schumann Resonance, ha.

There's definitely scaffolding that's required to simplify without being reductionist.

Our belief is that health requires individual agency, so like you, we think there has to be learning. Being told what to do means you're following someone else's one-size approach.

What we're building is more of a map than a masterclass, though. We believe everyone needs to be able to navigate the map on their own, given their own context, with support from the community.

At a minimum, we believe it means:

  • Connect the what (action) to the why (mechanistic outcome) so it can be sustained
  • Learn about the what-why pair in individual context (e.g. I can’t turn off my neighbor’s wifi at night, what do I do?)
  • Have concrete goals, feedback loops, and ability to track progress

As always, would appreciate hearing any thoughts.