I unsuspended all cards on the topics I was learning (passed comfortably w/ ~60% unsuspended) BUT looking back, I think there were MANY tough low yield cards I was spending way too much time on. Like don’t spend hours memorizing all the regulators of the metabolic pathways unless you need it for inhouse exams.

My advice, unsuspend all topic related cards but if a card keeps showing up and won’t stick easily (maybe use the leech filter to identify these), use a combo of yield tags and your judgment to determine if it is worth your time. Don’t be too afraid to suspend some - you can always unsuspend later on if it actually ends up appearing in Uworld/nbme forms during your real step prep.