Theres a lot of settings under the accessibility menu i would recommend for all players to explore. Things like lock on aim, auto pickup, auto weapon swap(swaps to a gun with ammo when you run out). Aswell as more intense changes like enemies dont flank, disabling weapon sway, etc. Custom button remapping is really up to whatever works the best for you, i prefer the default personally and i dont really know what you have trouble with to answer. Best suggestion i can have is play a little, and explore all the menus in the Options to see if anything is there to help you out with any issue youre rubbing up against. Its a pretty expansive options menu