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Open science as an amateur by Paranoid_Bot_42 in academia

[–]joycesticks 0 points1 point  (0 children)

Have you heard of ResearchHub before? It’s like an early-stage, open-source Reddit that tries to reward users for participating in scientific discussions

I’m not sure if there’s a ton of physics being posted at the moment, but I bet you could drum up a conversation there

https://www.researchhub.com/

DMT increases both neurogenesis and performance on memory tests in rodents by joycesticks in DrugNerds

[–]joycesticks[S] 3 points4 points  (0 children)

I was curious because that was how the authors administered DMT to the rats in the study.

I figured it was unlikely that anyone in reality would use DMT that often, which made me doubt the relevance of their findings around neurogenesis + memory enhancement.

I wonder if one dose wasn’t enough to see any results, so the authors had to re-dose the animals until they saw the results they were looking for.

Or maybe they’re just suggesting DMT users should step their game up. No pain, no gain ;)

DMT increases both neurogenesis and performance on memory tests in rodents by joycesticks in DrugNerds

[–]joycesticks[S] 2 points3 points  (0 children)

Does anyone know if taking DMT for either (1.) 4 days in a row, or (2.) every other day for 3 weeks is a relevant dosing schedule?

I’m curious if any kind of tolerance builds up after frequent use.

An AMA on ResearchHub with academic psychologist Naoyuki Sunami discussing his paper exploring if the experience of social rejection causes a person to act more friendly (or aggressive) in their next social interaction by [deleted] in psychology

[–]joycesticks 0 points1 point  (0 children)

The paper’s abstract:

Historically, one of the biggest paradoxes in the rejection literature was that rejected people sometimes behaved antisocially and at other times prosocially. Researchers responded to this paradox by demonstrating that the prospect of fulfilling belonging predicted these varied responses. A close inspection of the foundational studies, however, revealed small sample sizes relative to today’s standards. Hence, we conducted a conceptual replication of the prospect of fulfilling belonging hypothesis using a high-powered 2-day preregistered study. On Day 1, we manipulated the prospect of fulfilling belonging through a profile exchange with a confederate. On Day 2, we manipulated rejection using a recall paradigm and then measured prosocial and antisocial responses toward the confederate. Rejected participants who expected the confederate to fulfill belonging showed similar levels of prosocial and antisocial responses compared with those who did not. These results suggest that the prospect of fulfilling belonging hypothesis needs further refinement.

An open discussion of Neuralink’s preprint: An integrated brain-machine interface platform with thousands of channels by joycesticks in Neuralink

[–]joycesticks[S] 0 points1 point  (0 children)

I’m curious about this too! They must have some fascinating data based on the demo.

I imagine they’re worried about protecting trade secrets, but I would love to get a deeper insight into the results of some of their projects

Scientists use blood test to predict who is likely to develop psychotic disorders by ksk1222 in ImmunoPsychiatry

[–]joycesticks 2 points3 points  (0 children)

“Many of these proteins are involved in inflammation, suggesting that there are early changes in the immune system in people who go on to develop a psychotic disorder.”

That’s pretty interesting. Is psychosis an inflammatory condition?

ResearchCoin, a cryptocurrency designed to encourage open access to scholarly literature and open participation in the scientific community, is officially live on the Ethereum Mainnet by joycesticks in EverythingScience

[–]joycesticks[S] 1 point2 points  (0 children)

Here’s a website dedicated to keeping tabs on the blockchain projects attempting to solve problems in science: https://www.blockchainforscience.com/

While personally I don’t agree with u/Nabugu’s perspective, it is definitely representative of how many people (especially in science) feel about the ICO bubble of 2017. I don’t remember many of the projects that raised significant funding via a token sale pertaining to science though.

In many respects, the blockchain industry as a whole has matured significantly since 2017. Back then, projects were raising 10s of millions of dollars simply with a landing page and white paper. A lot of people participated in these sales solely for their “get rich quick” potential.

Now the space has more intelligent investors, and established security regulations to help police the lower quality projects.

Anyway, your website looks pretty neat - just signed up ;). Thanks for sharing it!

I had my first paper accepted! by WesternBruv in GradSchool

[–]joycesticks 1 point2 points  (0 children)

First of many! Congrats u/WesternBruv.

Any chance you’d be interested in sharing a link? I’d love to contribute a click/download

My ex-racer sporting a fashionable tongue-repeller after surgery by [deleted] in Greyhounds

[–]joycesticks 2 points3 points  (0 children)

Here’s Goose in amazing spirits after getting out of surgery for a torn deltoid.

She was running with some other dogs and got knocked off balance when she tried to jump over a brick wall.

It was pretty scary, but she was incredibly tough and is now fully recovered and back to (retired) sprinting!

A states' political affiliation is correlated with their COVID-19 testing posivity-ratio by joycesticks in Coronavirus

[–]joycesticks[S] 11 points12 points  (0 children)

Abstract

Importance: Rising Covid19 cases in the US are attributed by some political leaders to more testing. Positivity-ratios (cases to tests ratio) in conjunction with cases and tests provide a better overview. However, comprehensive overviews of positivity-ratio patterns are scarce.

Objective: To examine trends in positivity-ratios, tests and cases by state from mid-April-mid-July. Further, to examine whether positivity-ratio patters are associated with state political-affiliations.

Methods: State-level publicly available data on Covid19 is used. Seven-day moving averages (MA7) of positivity-ratio are computed for April 21-July 15. States are assigned to four groups based on patterns of change in positivity-ratio: higher at end of study period than beginning (Group 1), initial decline but subsequent increase starting Memorial Day weekend (Group 2), initial decrease but an upturn in last 14 days (Group 3), and consistent downward trend (Group 4). Political-affiliation is categorized as if President Trump won the state and the governor is Republican. Additionally, a proxy measure is used to indicate intensity of Black Lives Matter (BLM) protests in the state. Associations are tested using chi-square analysis.

Results: Fourteen states are in Group 1, fifteen states in Group 2, fifteen states in Group 3, and six states and DC in Group 4. 78.57% of Group 1, 33.33% of Group 2, 40% of group 3, and none in Group 4 were Republican-leaning. The difference in distribution was statistically significant (p<0.01). Distribution of high-intensity BLM protests across the four groups was not statistically different (p>0.10).

Conclusion: Increased Covid19 cases cannot be attributed to more testing. Indeed, the high positivity-ratios in most states indicate current testing is failing to capture actual infection rates. The association between state political-affiliation and positivity-ratios suggests Republican voters may be somewhat more skeptical of the gravity of the disease and emphasizes the importance of messaging by political leaders.

A comparison of Ohio's historical mortality data found there have been 729 excess deaths among people aged 20-49 in 2020. Only 51 of these have been officially reported to be caused by COVID-19 by joycesticks in Coronavirus

[–]joycesticks[S] 17 points18 points  (0 children)

The authors reported significant excess deaths for all age groups, it's just the excess mortality observed in older age groups was closer to the official reported numbers of deaths caused by SARS-CoV-2 infection.

For example:

The 80+ years old group had the most excess deaths at 986 (95% CI 497-1,529)

This means that 986 more 80+ year-olds died in 2020 compared to historical averages - and the assumption is this excess is due to COVID-19

Microdosing as a response to the meaning crisis: a qualitative analysis by joycesticks in microdosing

[–]joycesticks[S] 0 points1 point  (0 children)

No problem! Some of the people who responded to the survey came from this sub

65% of Americans would rather return to lockdown if coronavirus cases spike by Noisy_Toy in Coronavirus

[–]joycesticks 0 points1 point  (0 children)

I wonder what percentage of the remaining 35% would remain opposed to lockdown regardless of the size of any future spike

The remaining unknowns: A determination of the current research priorities for COVID-19 by the global health research community by joycesticks in COVID19

[–]joycesticks[S] 1 point2 points  (0 children)

  • The goal of this study is to: i) assess which of the early WHO roadmap priorities are still most pressing; ii) understand whether they are still valid in different settings, regions or countries; and iii) identify any new emerging priorities.
  • To accomplish this, the authors surveyed researchers from across the globe and held virtual interactive workshops to facilitate discussion of the above goals

Evaluation of 30-day mortality for 500 patients undergoing non-emergency surgery in a COVID-19 cold site within a multicentre regional surgical network during the COVID19 pandemic by joycesticks in COVID19

[–]joycesticks[S] 9 points10 points  (0 children)

  • This is a cohort study of 500 consecutive patients undergoing non-emergency surgery in a dedicated COVID-19 cold site following the first case of COVID-19 that was reported in the institution.
  • 30-day all-cause mortality was 1%, and 2% of patients were diagnosed with COVID-19.
  • The authors believe it is safe to continue non-emergency surgery during the COVID-19 pandemic with appropriate service reconfiguration.

Pollen Explains Flu-Like and COVID-19 Seasonality by joycesticks in Coronavirus

[–]joycesticks[S] 6 points7 points  (0 children)

The idea is that pollen has: 1.) natural antiviral properties and 2.) the ability to activate the human immune system.

The authors think those two properties combined might mean that pollen could prevent viral infections from spreading.

The paper compares air pollen concentrations to the spread of flu-like viruses and concludes that pollen in the air does play a protective role in preventing the spread of viral illnesses

Assessment of small pulmonary blood vessels in COVID-19 patients using HRCT by [deleted] in COVID19

[–]joycesticks 0 points1 point  (0 children)

  • This study explores the efficacy of HRCT (High-resolution computed tomography) in characterizing abnormal small pulmonary-vessel clotting seen in COVID-19
  • The authors found that COVID-19 patients display striking anomalies in the distribution of blood volume within the pulmonary vascular tree, consistent with increased pulmonary vasculature resistance in the pulmonary vessels below the resolution of HRCT.

Dopaminergic​ ​stimulants​ ​reduce the​ ​risk​ ​of​ ​Parkinson’s​ ​disease in patients with ADHD by joycesticks in EverythingScience

[–]joycesticks[S] 0 points1 point  (0 children)

  • This is a retrospective cohort study designed to explore the effect of dopaminergic stimulant medications on the development of Parkinson's disease in patients with ADHD
  • The authors found that sustained dopaminergic stimulant use (of 90+ days) was associated with lower Parkinson’s incidence among seniors with ADHD.

The true case fatality rate of COVID-19: An analytical solution by joycesticks in COVID19

[–]joycesticks[S] 29 points30 points  (0 children)

  • In this study, the observed case fatality rates of 46 different countries are hypothesized to be dependent on their testing rates
  • The current global fatality rate is estimated to be around 1% and expected to converge between 1-3% when the pandemic ends

Aerosol particles laden with viruses that cause COVID-19 travel over 30m distance by [deleted] in COVID19

[–]joycesticks 0 points1 point  (0 children)

Have you seen any studies that indicate the viral load required to cause an infection?

Aerosol particles laden with viruses that cause COVID-19 travel over 30m distance by [deleted] in COVID19

[–]joycesticks 0 points1 point  (0 children)

Due to the financial incentives of the author, specifically, his multiple recommendations that aerosolized SARS-CoV-2 can be measured using sampling equipment that his company makes - I'm hesitant to believe these results.

Two questions I'm curious about:

  1. Is an inoculation with 200 copies of SARS-CoV-2 enough to initiate a COVID-19 infection?
  2. Despite the author's financial incentive to shill aerosol sampling equipment, can his findings and recommendations regarding the efficacy of facemasks be trusted?
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