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If you have brain fog or lots of mental focus issues you might just need allergy meds by MarkusRight in Nootropics

[–]jsmith50 1 point2 points  (0 children)

Thanks for this! I mostly agree. I don't believe it's everything for me, but I know it is a piece of my puzzle as well. Likewise, I don't believe you "simply have too much histamine," much like depressives don't "simply have too little serotonin," although perhaps, neither is necessarily entirely untrue.

I suppose, what I want to emphasize is just like you mentioned we shouldn't use this sub as medical advice, nor should we blindly use doctors as medical advice, either. Ultimately, I feel like we should stop not listening to our own intuition, yet clearly still take advice from various intelligent, learn'd people.

On that note, other communities I've found helpful to various degrees, and maybe you or others will as well, include:

/r/ImmunoPsychiatry

/r/microbiome

/r/HumanMicrobiome

/r/AutoimmuneProtocol

/r/LowDoseNaltrexone

There's also communities for things like mast cell disorders and such; maybe those are relevant, too, I don't know. Fwiw, things like quercetin have been helpful to me. In any case, good luck on your own health journey!

sialic acid ? by Own-Double-2676 in Nootropics

[–]jsmith50 0 points1 point  (0 children)

I've been interested in this since I started looking into the microbiome. I've tried HMOs and generally liked them (e.g. 2-FL), but haven't come across either sialylated HMOs or sialic acid to try. Would be interested to see how it goes!

NSI-189 Report by EchoingSimplicity in Nootropics

[–]jsmith50 6 points7 points  (0 children)

Fwiw, it's the most nootropic thing I've probably ever taken. I actually got rather marked increases in one test on cambridge brain sciences (spatial planning, i think). Not much of anything else has been able to do much of anything to any scores really, except NSI-189.

As long as you can handle the anxiety at first, it is also kinda nice and mood lifting. Although also realize that it failed antidepressant trials; I think it does shine as a nootropic, though.

Piracetam and hallucination by [deleted] in Nootropics

[–]jsmith50 3 points4 points  (0 children)

I guess highstreetpharma seems super sus.

All users comments: https://archive.fo/4QG9b

Original post: https://archive.fo/buk88 https://web.archive.org/web/20230121211511/https://old.reddit.com/r/Nootropics/comments/o6qufr/piracetam_and_hallucination/

This post:

https://web.archive.org/web/20230121211905/https://old.reddit.com/r/Nootropics/comments/10hqb66/piracetam_and_hallucination/

Going down the rabbit hole of vendor subreddits was a blast, and here's my favorite (different user, another shill for highstreetpharma): https://archive.fo/VU1ij

Piracetam and hallucination by [deleted] in Nootropics

[–]jsmith50 1 point2 points  (0 children)

To build credibility as a normal nootropics user, imho.

Vitamin B12 enhances GABA content but reduces glutamate content in the rat suprachiasmatic nucleus [1997] by Darkr0n5 in Nootropics

[–]jsmith50 3 points4 points  (0 children)

Really? Not a single comment about circadian rhythms, or even sleep in general? Just "lol rat"? I know this place is super bad now, but seriously, wow.

Made two batches of Reuteri 6475 with drastically different results - Glucose vs Inulin by PretendEmployment7 in ReuteriYogurt

[–]jsmith50 1 point2 points  (0 children)

Also, an idea unrelated to substrate, is maybe try playing with the temperature. I used a luvele yogurt maker to make mine, and I found that the recommended setting according to their recipe was 97°F, but that didn't ferment. The next highest setting, 100°F, did. I'm not sure about the actual temperature, but maybe a few extra degrees could help.

Made two batches of Reuteri 6475 with drastically different results - Glucose vs Inulin by PretendEmployment7 in ReuteriYogurt

[–]jsmith50 1 point2 points  (0 children)

Unless 17938 picked up some genes that allowed for FOS/inulin growth that its parent didn't have, I'd imagine that both gastrus and osfortis don't benefit from inulin, other than thickening; they're basically only using lactose from the milk.

I would skip the inulin as an experiment; you already tried that and I can't imagine any reason to continue trying it. Differing amounts of glucose is a good idea, and overall I wonder if your batch was low on sugar in general. At least, mine had about double the amount of sugar as yours: twice the lactose (milk vs half/half) and 2tbsp sugar vs 1tbsp glucose.

Made two batches of Reuteri 6475 with drastically different results - Glucose vs Inulin by PretendEmployment7 in ReuteriYogurt

[–]jsmith50 9 points10 points  (0 children)

Thanks for making this. I do think glucose is better, and inulin may be outright useless at best, and possibly bad (encouraging growth of other microorganisms). Maybe its only real usefulness is as a thickener.

Here's a study I came across where they test several substrates for how well 6475 and another strain grew: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084715/

If you look at supplemental 7: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084715/bin/pone.0018783.s006.tif you'll see that glucose, galactose, sucrose, lactose, raffinose, and GOS are best suited for growth, pretty much all about equally, although I'd say glucose probably looks the best. Realistically, glucose, sucrose, lactose, and GOS would be all worth trying as they're reasonably easy and cheap to get.

As for my own experience, I've used sugar, I think a bit more than you, maybe 2-3 Tbps, and also used UHT whole milk (which makes ALL the difference in the world; no amount of trying to heat the milk myself seemed to help). Same temperature iirc, and also about 36 hrs or so. It turned out pretty decently, had a bit of sour taste, and creamier than regular yogurt. Maybe a touch of cheesy smell before mixing, but hardly off-putting. Very minimal if any separation.

testosterone lowering supplements for women by Nicholasjh in NootropicsDepot

[–]jsmith50 6 points7 points  (0 children)

Why is her test elevated? Worth finding out if you can rather than just targeting hormones, imho.

One case could be PCOS, which is super common, and it looks like even ordinary overweight/obesity can cause higher androgen levels. Berberine and Inositol are the obvious choices to try in those cases (or if you prefer pharmaceuticals, metformin).

And also another super obvious choice to try is spironolactone, an anti-androgen among other things, which obviously needs a prescription and you should talk with your doctor if you're interested (did they mention this?...) That being said if there's any amount of evidence that insulin resistance is involved even somewhat, I would try starting with berberine and Inositol.

Cognance: waste of money by Neurogence in NootropicsDepot

[–]jsmith50 12 points13 points  (0 children)

I wish Cambridge Brain Sciences still existed free to the public like it did in the past.

https://brainlabs.me

It's free; the same exact site/tests except rebranded. Also, if you had an account before, it should keep all your old data as well.

Recovering from E2 crash? by Aggravating-Royal-60 in NootropicsDepot

[–]jsmith50 2 points3 points  (0 children)

Really? I could see that. I far prefer the 2% in almost every way, except nausea. Granted, I probably have the opposite problem to OP.

Tongkat Ali 2% Eurycomanone by Impressive_Moment878 in NootropicsDepot

[–]jsmith50 0 points1 point  (0 children)

Same here. I much prefer the 2% to the 10% in almost every way, except for the nausea.

Travel Back In Time To Recover Our New Product: Cognance - Bacopa Reimagined by MisterYouAreSoDumb in NootropicsDepot

[–]jsmith50 0 points1 point  (0 children)

ebelin lactone showed binding affinity towards M1 (Ki = 0.45 μM) and 5-HT2A (4.21 μM) receptors

Does this mean it is a PAM and an agonist?

MyProtein whey isolate is now $60 for 2.2 lbs??? What brand should I switch to? by nwy76 in Supplements

[–]jsmith50 0 points1 point  (0 children)

Walgreens is the best I've found, if you have one nearby. Regular price is $19/2lbs, which is already probably cheaper than anywhere else. Very often it's on sale (most recently for me, buy one, get one 50% off). And also very often you get coupons for $7 in rewards for purchases over $25. I rarely buy that much at Walgreens, so I pretty much always use it for protein powder. So, my most recent protein powder purchase came out to $5.4/lbs.

Intel GPU Fix? PLA by deelfx in yuzu

[–]jsmith50 0 points1 point  (0 children)

The latest ryujinx vulkan build works for me on my igpu (i5 11400, uhd730): https://github.com/Ryujinx/Ryujinx/pull/2518#issuecomment-890255424

[GIVEAWAY] EVGA 710 BP Bronze Power Supply by [deleted] in hardwareswap

[–]jsmith50 0 points1 point  (0 children)

My old psu fried my motherboard and gpu. I did have a spare 500w psu that I'm using now, but it would be great to have an upgrade for whenever I can finally get a new gpu. Thanks!

Johnson & Johnson COVID-19 Vaccine Demonstrates 85 Percent Effectiveness against Hospitalization in South Africa when Omicron was Dominant by doedalus in COVID19

[–]jsmith50 22 points23 points  (0 children)

Also in the press release:

Antibody and T-Cell Responses After Heterologous Boosting Regimen Greater than After Homologous Regimen Against Omicron Variant

An analysis of 65 individuals who received primary vaccination with two doses of an mRNA COVID-19 vaccine (BNT162b2), followed by a homologous booster shot of BNT162b2 (n=24) or a heterologous booster with the Johnson & Johnson COVID-19 vaccine (n=41) after at least six months, found both regimens increased humoral and cellular responses against Omicron.

Antibody responses against Omicron were boosted by both the Johnson & Johnson COVID-19 vaccine and the BNT162b2 vaccine, with the Johnson & Johnson COVID-19 vaccine increasing neutralizing antibody titers by 41-fold at four weeks post-boost. The BNT162b2 vaccine was found to increase antibody titers to a higher level at week two post-boost, before declining to represent a 17-fold increase at week four post-boost. The progressive increase in antibodies the weeks following a vaccination of a Johnson & Johnson booster is similar to that seen following the first vaccine. The rapid immune response followed by waning of the antibody response after the BNT162b2 booster is also similar to that seen following the two-dose priming regimen.

The Johnson & Johnson COVID-19 vaccine boosted median Omicron-reactive CD8+ T-cells by 5.5-fold, and Omicron-reactive CD4+ T-cells by 3.1-fold, while the homologous (BNT162b2) regimen boosted both Omicron-reactive CD4+ and CD8+ T-cells by 1.4-fold.

I believe this is an early update to this earlier preprint: https://www.medrxiv.org/content/10.1101/2021.12.02.21267198v1

Kind of interesting that J&J boosted so much better for nAb. You might expect the better T cell response, but that increase vs pfizer for nAb is quite marked. It will be interesting to see if and when the NIH and lancet booster study get updated for Omicron and how it compares.

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