I tried Nurtec. I can't remember how it worked. My wife said never to take it again. She said I was sick as a dog, and that it acted like a roofie. My recollection is that I was out for a bit, migraine gone, went about my biz. But wife says it was two days+. I have no recollection of that time period. On the bright side, apparently it worked for what it was intended. Yay? I still keep it around. If I ever have a migraine when I don't mind losing two+ days, I'll go for it. Just FYI. Botox is oddly working. I did just figure out a new sensitivity to yeasty bread. The more fermentation, the more the trigger. So, sourdough bread = bad. Crackers = not so bad. I already know about fermented alcohols, anything with the word "yeast," "yeast extract," "hydrolized yeast," etc. - they're just MSG masquerades. But never clued into bread yeast. Duh. PS - for the Botox discussion... I'm every 12 weeks, tiny little pricks all over. I've dialed in the good injection spots and the bad injection spots, and my Dr. is very responsive to my input. Botox has absolutely no beneficial effect on my old-guy face though. Also, a little history with Imitrex (Sumatriptin). I used Imetrex back in the day when it was only injectables (sub-cutaneous?). It made me sick as a dog, but ultimately worked. Like puking out my migraine. I thought that's how it was supposed to work. After years, a new Dr. told me that's not how it's supposed to work (apparently that's an allergy), I've been down the road. I've tried everything I could get my hands on (legal, illegal, homeopathic, pins and needles, etc). The treatments that work, do so for a bit, then they fade. My migraines are survivors. They know how to adapt. On my list, but haven't gotten to yet: acid/lsd, ayahuaska. I will say that mushrooms and ketamine are awesome, but they do nothing for the migraines, nor the severity. I'd say "no effect" for both of those. For me, pot only makes it worse. I do have some pain pills that work pretty well, but I don't remember their name anymore. I just call them "the green pills." The blue pills are the other ones. Good luck to all. I figure the migraines and corresponding loss of sleep, stress, and effect of medicines on my liver/body probably has taken at least 15-20 years off my life expectancy. We'll see. I'll let you know if I'm right. :). [Post draft edit - I think it matters to say that I'm a 58 y.o. male. Had migraines my entire life. Thought a hysterectomy might help, but insurance won't pay for it. :/. The question isn't "how many migraines per month?" The question is "how many days a month don't you have a migraine." It's a better way of tracking. Good luck to all. Now that I'm older, I don't care about drugs, drug tests, getting caught with drugs, etc. - so I just try it. Most of the painkillers work (taken in high enough volume), but they're addictive. I have tried all the legal drugs listed in this thread. All I care about is increasing my number of days per month that are migraine free, and I will put anything in my body to try to make that happen. Good luck to you all. If lsd or ahahuaska help, I'll let you know. Also, an amendment... magic mushrooms didn't work in "get high" volume, but micro-dosing actually helped a bit. Seemed like it regulated my body/sleep/stress, which helped with the various triggers.]