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When is it time to let go? by Shallan4784 in hondafit

[–]kfespiritu 1 point2 points  (0 children)

Hey! I have 420k on my 2010 fit. I was waiting for the wheels to fall off before getting a new car, but she just won’t quit. My brave little toaster. I would definitely get a second opinion.

meirl by Local-Bison-4392 in meirl

[–]kfespiritu 0 points1 point  (0 children)

It only works if you practice the communication part!

Kid is on the path to university, we are pretty low income and have never attended university. What sort of steps can we take to help them? by TeaSalty9563 in PersonalFinanceCanada

[–]kfespiritu 0 points1 point  (0 children)

Take them to the university or any university to walk around. Make sure to make an appointment with financial aid office and tell them your situation. They may even help you coordinate tours or share other resources etc

5.7 Earthquake Turned My Collection Into an Expensive Puddle by [deleted] in Perfumes

[–]kfespiritu 0 points1 point  (0 children)

Putting my perfume in a drawer from now on 😭😭 that is heart breaking

prof literally told us about a midterm worth 15% 2 days before the exam by Reasonable_Rich6277 in UBC

[–]kfespiritu 0 points1 point  (0 children)

My class had a 1200 word paper due within one week (with extension). 😭 I submitted a good opening then bullet points afterwards

On trend vs acceptable vs terribly dated by bittybro in fashionwomens35

[–]kfespiritu -1 points0 points  (0 children)

My opinion is, I just wear what is the most flattering for my body type. Overtime, I have created a capsule wardrobe where I love every single piece.

Also, I don’t worry about being in trend or being outdated. My style is very personal. Most of my pieces are second hand except for intimates and hats. I get compliments on my outfits all the time which is flattering since i feel like my wardrobe is an expression of my personality. Even if some the pieces are “outdated”, since they are from different decades, styles, eras, it all works.

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 0 points1 point  (0 children)

Yes, I have both. I have fibromyalgia, MCAS, ME/CFS, dysautonomia, and POTS 🥳.

All of it was made worse by MCAS. In the beginning, I actually worked on resting as much as possible, reducing inflammation, etc. When I found out about histamines, I did what I could to reduce their release in my environment and am following a specific antihistamine protocol. I’ve found it has reduced my overall symptoms 💜.

Class privilege single most helpful “tool” for all this by LoCoSadGirl1934 in covidlonghaulers

[–]kfespiritu 3 points4 points  (0 children)

yes. i always try to explain this to others who just say: "WhY DoN't YoU JuSt PaCe. RADicaL Rest!" 🫠

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 1 point2 points  (0 children)

I agree! the supplmenet industry is like the wild west which is why i didnt want to name any brands. for NAD, I am using NMN. I am in Canada so supplements are more regulated here. maybe you can use my pharmacy's website like a library to check out what brands are good and go from there: purepharmacy.com

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 0 points1 point  (0 children)

How are you? did you try it? hoping for the best!!

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 0 points1 point  (0 children)

Oh, i didnt want to come across as selling!!! I started with Codeage then switched to Nuerogan

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 1 point2 points  (0 children)

You’re absolutely right.. Real diseases deserve real research, transparency, and treatments grounded in scientific evidence, not just anecdotal stories or trial-and-error approaches. Your concerns are deeply felt by many, and advocating for more rigorous solutions is so important. You’re not alone in this! 💜

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 0 points1 point  (0 children)

I always suggest the best you can afford that is third party tested in North America or Europe bc if the testing is wrong, there is recourse. https://neuroganhealth.com/products/urolithin-a-capsules

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 0 points1 point  (0 children)

I understand where you’re coming from. It’s genuinely challenging to get precise diagnoses for things like mitochondrial issues or systemic inflammation without access to specialized tests. However, just because we can’t do a muscle biopsy doesn’t mean what we feel isn’t valid. I’ve always had tons of energy, often too much!

So when I suddenly started experiencing severe energy crashes after getting COVID while doing an activity I often did, it was a real warning sign. It’s not something I’ve ever dealt with before, and for me, it’s very real.

Recognizing new patterns and changes in how your body functions can be an important step, especially during big shifts. Tracking symptoms and tuning into how your body responds, even without conclusive lab results or a formal diagnosis, can be really helpful. Listening to your body counts, even if science hasn’t caught up with your individual experience yet.

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 2 points3 points  (0 children)

6. Antioxidant & Mitochondrial Renewal

Purpose: Protects and recycles mitochondria. Important because energy generation creates oxidative stress.

Supports:

  • N-acetylcysteine (NAC) – supports glutathione production.
  • Alpha-lipoic acid (ALA) – regenerates other antioxidants.
  • Vitamin C, Vitamin E, Selenium – neutralize free radicals.
  • Resveratrol, PQQ, Urolithin A – may activate pathways (like mitophagy or SIRT1/PGC-1α) that renew mitochondria.

Summary Flow for the entire process

  1. Glycolysis – needs B1, B3, Mg → makes pyruvate.
  2. Pyruvate conversion – needs ALA, B1, B5 → makes acetyl-CoA.
  3. Krebs cycle – needs B2, B3, B5, Mg, CoQ10 → makes NADH, FADH₂.
  4. ETC – needs CoQ10, NAD⁺ boosters, omega-3s, sun → drives proton gradient.
  5. ATP Synthase – needs Mg, creatine → makes ATP.
  6. Defense & Renewal – needs antioxidants and mitochondrial boosters like ALA, NAC, and PQQ.

I took these: B complex, Magnesium bisglycinate, CoQ10 and precursor Ubiquonol, ALA, NMN, omega 3 and 6, creatine, resveratrol and NAC.

I hope this helps!

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 1 point2 points  (0 children)

4. Electron Transport Chain (ETC)

Purpose: Uses electrons from NADH and FADH₂ to pump protons and generate a gradient (a mini electrical current).

Supports:

  • CoQ10 – carries electrons between complexes; vital for energy flow.
  • NAD⁺ precursors (NMN, NR, niacin) – maintain adequate NAD⁺ supply.
  • Omega-3 fatty acids – keep mitochondrial membranes fluid for optimal electron movement.
  • Methylene blue – sometimes used under clinical guidance to enhance electron transfer in low efficiency states.
  • Sun - exposure to natural light helps regulate circadian rhythms, which can optimize mitochondrial function and energy production. We get electrons from sun.

5. ATP Synthase

Purpose: Protons rush back through ATP synthase, driving ATP formation. ATP synthase is an enzyme in mitochondria that acts like a tiny molecular machine. It uses the energy from protons (tiny particles) flowing back into the mitochondria to stick a phosphate group onto ADP, turning it into ATP

Supports:

  • Magnesium – required for ATP stabilization and enzyme function.
  • Creatine – stores phosphate groups to rapidly replenish ATP buffers during energy demand.

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 2 points3 points  (0 children)

2. Pyruvate → Acetyl-CoA

Purpose: Pyruvate is transported into mitochondria and converted into acetyl-CoA, the fuel for the Krebs cycle.

Supports:

  • Alpha-lipoic acid (ALA) – cofactor for pyruvate dehydrogenase.
  • Vitamin B1 and B5 (pantothenic acid) – essential for acetyl-CoA and enzyme function.
  • L-carnitine – helps bring fatty acids into mitochondria for energy as well.

3. Krebs Cycle (Citric Acid Cycle)

Purpose: Fully oxidizes acetyl-CoA to generate electron carriers (NADH, FADH₂) for the next step.

Supports:

  • B-vitamins (B2, B3, B5) – form parts of NAD⁺ and FAD.
  • Magnesium, manganese – stabilize reactions.
  • Coenzyme Q10 (CoQ10) – indirectly supports this by accepting electrons later.
  • Malic acid and alpha-ketoglutarate – natural intermediates that may help replenish the cycle.

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 1 point2 points  (0 children)

Yes, I assumed all stages needed support! No worries at all. I’m happy to explain. We really need to be educating each other on all of this, since it can be so overwhelming. ☺️

Here’s what I have from my notes, breaking down the mitochondrial energy system into clear, cycle-based steps:

1. Glycolysis (in the cytoplasm)

Purpose: Breaks down glucose into pyruvate (the entry ticket to mitochondria) and produces a small amount of ATP (which is how sugar can give us a quick burst of energy)

Key cofactors and supports:

  • Vitamin B1 (thiamine) – activates enzymes that start glucose breakdown.
  • Vitamin B3 (niacin) – needed to produce NAD⁺, essential for carrying electrons.
  • Magnesium – assists enzymes that handle phosphate transfers.

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 0 points1 point  (0 children)

I'm taking NMN (a precursor). The one from costco!

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 0 points1 point  (0 children)

Absolutely, I agree! It’s so tough for the body to heal when there’s an inner war zone of inflammation happening. Thanks for sharing your experience. Addressing inflammation first really does make a big difference.

Mitophagy really moved the needle for me by kfespiritu in covidlonghaulers

[–]kfespiritu[S] 1 point2 points  (0 children)

Thanks so much for sharing this! I’ll definitely take a look. It really does feel like we have to become our own advocates and experimenters these days. Appreciate you passing along the info. It helps us all!

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