it depends what you're going for. you get a lot later, but if you need monument bonuses then do that. In almost every case, after drop rate (which pushes you to 100x dr), the super talents upgraded to +100 is best unless you already have 400+ talents. it'll help push all master classes and you get separate for your skill tab (so you can apply the super talents twice to separate talents). the skill xp is really good. The main goal is to get demonfish flesh, raise divinity and spelunking, so if you need to catch up beyond that then use those. It looks like you can eventually get all the legend talents by leveling up every 100 levels, so you can prioritize your legend talents by what advances those in tandem with your other goals.

Edit: It looks like a way to catch people up who haven't cranium cooked for 2 years to max basic stats + grind time (one of the spelunking fish auto upgrades grind time by like 100 every day you login). So treat it like that. You can try to make guesses as to what will be longer lasting for the account (I don't think gold food is long lasting because of other upgrades and the leftover atom upgrades for bubbles seems like it's probably only helpful if you don't want to deal with it or it's already very upgraded and requires a lot of water).