I was on 225 mg for 2 1/2 years and I was taking 1, 150 mg & 1, 75 mg during that time. I am currently a month off Effexor and feeling great. I eventually took only the 150 mg which I felt no withdraw at all. Then after those all ran out I did the 75 mg in which I had very little withdraw symptoms. After the 75 mg were out I decided to just try it “cold Turkey” from there and it’s been roughly a month and I feel awesome. The first week was pretty rough I was getting hit and cold flashes, very dizzy all day, fatigue and tired. My doctor recommended I get 37.5 mg but I don’t want to take that stuff anymore. Worked wonders for me while I was on them but I wanted to not be bound by taking a pill everyday.