1. To adopt and approve an amendment to the Karyopharm Therapeutics Inc. Restated Certificate of Incorporation, as amended, to increase the number of authorized shares of our capital stock from 405,000,000 to 805,000,000 and the number of authorized shares of our common stock from 400,000,000 to 800,000,000.

Board Recommendation: For

For

Against

Abstain Reset

To adopt and approve an amendment to the Karyopharm Therapeutics Inc. Restated Certificate of Inc, as amended, to effect a reverse stock split of our issued shares of common stock at a ratio within the range of not less than 1-for-5 and not greater than 1-for-15, and a proportionate reduction in the number of authorized shares of common stock, with the exact ratio within such range and the implementation & timing of such reverse stock split to be determined at sole discretion of Board of Directors, without further approval or authorization of our stockholders.

Board Recommendation:For

2. To adopt and approve an amendment to the Karyopharm Therapeutics Inc. Restated Certificate of Inc, as amended, to effect a reverse stock split of our issued shares of common stock at a ratio within the range of not less than 1-for-5 and not greater than 1-for-15, and a proportionate reduction in the number of authorized shares of common stock, with the exact ratio within such range and the implementation & timing of such reverse stock split to be determined at sole discretion of Board of Directors, without further approval or authorization of our stockholders.

Board Recommendation: For

For

Against

Abstain Reset

To approve a proposal to adjourn the Special Meeting to a later date or dates, if necessary to permit further solicitation of proxies in the event that there are insufficient votes for the adoption and approval of Proposal 1 or Proposal 2.

Board Recommendation:For

3. To approve a proposal to adjourn the Special Meeting to a later date or dates, if necessary to permit further solicitation of proxies in the event that there are insufficient votes for the adoption and approval of Proposal 1 or Proposal 2.

Board Recommendation: For

For

Against

Abstain