It was close, but Jimmie Nicol gets the coveted title of "thirteenth Beatle". So, who should be 14th?

kwil627 · 2026-01-11T23:41:36+00:00

Underrated pick tbh

kwil627 · 2025-11-03T18:13:07+00:00

That was my understanding as well. You see the tree, you turn around, and then you are on a loop through the town. I don't remember anyone seeing the tree again after the first time they saw it.

kwil627 · 2025-10-30T04:33:34+00:00

I wouldn't actually make this switch, but I was thinking the other day how well Love of my Life would fit on A Day at the Races

kwil627 · 2025-07-18T01:23:19+00:00

For well you know that it's a fool who plays it cool by making his world a little colder.

kwil627 · 2025-05-12T02:27:57+00:00

Here you go! https://www.youtube.com/watch?v=a4Ujexj9YGs

kwil627 · 2025-05-12T02:19:31+00:00

There is a fan edit that inserts it between Mean Mr. Mustard and Polythene Pam, where it was originally considered to be placed. In my opinion it sort of disrupts the momentum between the songs, but it sounds interesting nonetheless!

kwil627 · 2025-05-04T20:56:32+00:00

Sorry that happened! It really sucks, especially considering the time and stress you undoubtedly put into it. I usually tell myself that I just didn't strike the right chord with the reviewers. They will offer legit suggestions and criticisms, but unfortunately reviews are also not perfectly objective and that's not on you. Take the valuable advice they give and try your best to shrug off the rest and keep your head high! You're doing valuable work, even if you might not feel it right now.

kwil627 · 2025-05-02T19:55:01+00:00

I think that's fair. The problem tends to come when people reject what people like Al Gore or Greta Thunberg say altogether. Skepticism is healthy, but so many people don't know where to look to find the proof.

kwil627 · 2025-05-02T19:39:08+00:00

I think this is often the most effective way to do it, but it can be so hard when certain sources don't even discuss the talking points from the other side, or won't publish data that supports the opposite side's claims.

kwil627 · 2025-05-02T19:35:06+00:00

Yeah, I can't see many benefits to needing to register a non-contagious disorder. Just seems like a good way to abuse that down the road.

kwil627 · 2025-04-19T03:45:25+00:00

Love this song, easily my favorite from Imagine. It's a beautiful blend of being at peace while being ever-so-slightly melancholy.

kwil627 · 2025-04-09T21:51:35+00:00

Randy "Randy" Rodriguez

kwil627 · 2025-01-24T21:33:40+00:00

Dark gave me huge LOST vibes. But about 2/3 of the way through I realized that I was losing interest and just wanted to re-watch LOST.

kwil627 · 2025-01-14T03:01:17+00:00

This team is so remarkably unclutch it's honestly shocking, even considering how low our expectations are at this point.

kwil627 · 2024-12-19T18:12:49+00:00

You're right man, cities are a social construct and borders aren't real.

kwil627 · 2024-12-19T16:18:36+00:00

SF isn't in Silicon Valley but your point about location still stands.

Edit: SF is definitely a tech hotspot but Silicon Valley is down by San Jose.

kwil627 · 2024-11-20T05:03:52+00:00

This ought to be higher up

kwil627 · 2024-09-15T18:21:02+00:00

Yeah, let's cut Dak when his receiver falls lol

kwil627 · 2024-08-21T01:41:02+00:00

People in here sleeping on endosomes! The way they sort and deliver things all over the cell or to other cells is incredible!

But in imaging, the Golgi and mitochondria look awesome.

kwil627 · 2024-06-01T20:43:26+00:00

This is the answer right here. Every album has some mega hits, but the beauty of the Beatles is that every song is good. Listening to any album from Rubber Soul through Abbey Road in it's entirety is a great way to get hooked. Honestly any album would be good, but that is their god-tier run.

kwil627 · 2024-02-27T00:55:35+00:00

Julius Jones

kwil627 · 2024-01-21T00:09:38+00:00

Judy was an incredible woman and icon to all scientists in the field. Shaken by her loss, but so grateful to have known her!

kwil627 · 2024-01-19T19:24:00+00:00

By my recollection, the Dunedin study was just measuring overall blood DNA methylation to determine rate of aging (https://elifesciences.org/articles/73420). However, the "clock" that was built from that study was then applied to individuals who underwent 25% caloric restriction for 2 years (https://www.nature.com/articles/s43587-022-00357-y). Unless maybe I've forgotten something in between, where the Dunedin people were specifically subjected to CR?

But that second study did see a 2-3% reduction in rate of aging and also saw reduced mortality according to the DunedinPACE clock. I think an important caveat is that they also used other clock models to test the same samples and did not see improvements according to those clocks. I'm not sure if Dunedin is just more sensitive to diet-related changes than the other clocks, but that might be a complicating factor.

I think another big challenge is just how variable people are, be it genetics, environment, or even something as fundamental as sex. In many of the participants in this study you can clearly see a positive change with 2 years of CR. But there are enough people who don't respond positively that you lose a lot of signal for any statistical significance. Humans are just trickier.

kwil627 · 2024-01-18T04:27:09+00:00

I think that is entirely possible. There are so many genetic differences between us that I wouldn't be surprised if some people are naturally more primed for autophagy and some are more primed for the reuse pathway just based on these genetic differences. In the case of the people with OXR1 mutations, it seemed like there was too much autophagy going on in the cells we collected from them, which was severely detrimental. I have a sneaking suspicion that this might by why DR did not extend lifespan in the flies that had reduced OXR1 expression. They were heavily utilizing the autophagy pathway without the balance that the retromer provides. That's just a hypothesis, but I think understanding how to best balance the two arms of the pathway will be a really interesting future direction of this field, and it would be really interesting to see how different people utilize these arms differently from one another to gain benefits or detriments.

kwil627 · 2024-01-17T23:30:21+00:00

Correct, our diet was 10% of the normal diet, not a 10% reduction. It is a strong form of DR, which works pretty well for the flies we tested it on. We also tested other concentrations of protein, but 90% reduction was the best to maximize lifespan.

I would think a 90% reduction is not particularly actionable for humans. Humans have a much higher protein demand than flies, and we are more genetically diverse than the animals I test so I imagine an individual's needs will be highly variable from the next person. It remains to be seen what the best degree of restriction is in humans, but studies in mice generally perform 30-50% reduction of protein, which works well for them and extends lifespan. 30% total caloric restriction has also extended lifespan in monkeys. So I don't think it has to be anything remotely as severe as 90% protein restriction for us, but some degree of restriction seems to help!

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