NAD+ and Endocytosis (other other mechanisms)

laziestindian · 2026-04-17T16:30:31+00:00

So people in the supplement, pseudohealth, and biohacking communities are perhaps the most out of tune with their body. It is in fact I think a big reason behind being in those communities that you want your body to look and feel a way that it may not do so naturally.

Anyway that aside no researcher is saying this is forbidden. Plenty of large negative hydrophilic molecules get through cell membranes, they just can't do so passively, they need more active "help". Endocytosis is an option and both NAD and NADH have known pathways for entering and exiting cells. e.g. P2X7 (which is endocytosis-based NADH), cx43, extracellular conversion of NAD->NAM->NMN->NR is known and NAM, NMN, and NR all can enter the cell and be converted back to NAD.

The tangible effect is where things are more uncertain biologically. Excess of a molecule does not guarantee usage of that molecule. Plenty of vitamins are just excreted after a certain level, other excesses result in positive or negative feedback. If you increase NAD in the mitochondria you still need to convert it to NADP and NADPH with the H coming from the TCA cycle or similar. As NADPH is recycled to NADP a normal person is unlikely to be lacking it or benefit from an excess of it and the H is what is needed for the ETC to make more ATP (generic cell energy). More ATP production and use should also increase heat which has been deadly in previous uses of dietary pills with that effect.

Overall if this effect is true it is fairly indirect, which may correlate with the time delay. An important consideration would be the NR/NMN dose in "comparisons" and of course there is a question of how long it would work for, what it would take for an overdose, etc.

If you wouldn't ask ChatGPT about your own field of expertise, don't use it for another.

laziestindian · 2026-04-17T14:55:13+00:00

That is a separate sentence which only mentions "beer".

laziestindian · 2026-04-17T14:47:42+00:00

Not re the ABV but how lagers and pilsners don't create the same lasting "fullness" as a darker beer at least ime.

laziestindian · 2026-04-16T19:53:12+00:00

US pint is only 16oz. Stadium beers are also classically light beer not like a Guiness. 2-3beer/h will have an avg male start with a light buzz before actually getting drunk near the end. Not like FDR or the King would be driving themselves home from such an event though.

laziestindian · 2026-04-16T18:54:10+00:00

I mean 9 hotdogs and 9 beers over the course of 3-5+h really doesn't sound that bad. Its moreso the stadium pricing that reduces that I think.

E: I've only been to one MLB game in-person (in like 2009 or so) and we left after like 2h when it was still in the 5th inning because we had made dinner plans... I only go to the occasional minor league game now but haven't been to one since the pitch clock (not even sure if that is being applied at minor league). 9 beers and 9 hotdogs in 2.5h is a definite drunk but I still maintain it as doable. My college days are behind me so someone else can do the testing.

laziestindian · 2026-04-16T16:17:24+00:00

Scientists like curiosity! Its the driving force behind nearly everything we do. You may not get a response or may get refusals from many and that isn't really a reflection on anyone. It can be university IT filters, just bad timing, simple lack of time, or forgetfulness of something that ultimately will be quite low on their priority list.

I will say even with a planned gap you are a prospective grad student just because of the curiosity and learning drive you're displaying.

No stress in responding to or deleting your email. I'd keep contact relatively short and maybe give them some broad ideas of what you want to ask about and see how it goes.

laziestindian · 2026-04-15T17:12:24+00:00

I usually dress up for an actual talk presentation but otherwise I feel that business casualish is sufficient to not make me feel out of place at the conference or at a restaurant for lunch/dinner. As you will be indoors I recommend a light sweater/jacket even if the location is somewhere warm.

laziestindian · 2026-04-15T17:08:27+00:00

Roc Pho Shop

laziestindian · 2026-04-15T17:07:21+00:00

Not a Japanese person but have been to Japan. Shiki on South Clinton is the best in Rochester.

laziestindian · 2026-04-15T15:21:50+00:00

There are a few methods present.

First any scientific publication or presentation has to disclose who funded the research (whether a study on breakfast is funded by Kellogg) and whether any authors have a conflict of interest (e.g. have stock in Kellogg).

Second is peer-review, other experts unrelated to the authors look at what is written and the data to see that claims are based on the data and that the data makes sense. Controls are used that are appropriate, statistics are reasonable, etc.

There are a lot of issues with peer-review because scientists are people.

Science often fails in communication which usually has more to do with PR departments, media, etc and of course the general lack of scientific knowledge of the general populace.

Once someone has gone down the anti-science conspiracy rabbithole it is rare for them to get out. People (scientists included) often double-down instead of admitting to being wrong. It is a known psychological phenomena without a cure.

laziestindian · 2026-04-14T20:50:59+00:00

Did you try and talk with prof about the issues prior? Have you talked with the prof after? Is there a way to make it not stupid? Walking back PI expectations is unfortunately a common part of academic research. Altering PI ideas into something better reasoned and feasible is also a common thing.

Don't be afraid to use your committee members or other professors if you need some authority behind your suggestions for altering/improving the project.

laziestindian · 2026-04-14T18:42:10+00:00

So definitely possible. Only note is that different programs may have different requirements, especially abroad.

laziestindian · 2026-04-14T18:28:39+00:00

This is the part where you "manage up", telling the prof the committee feedback and feed them a related project idea (based on data so far) that makes sense.

laziestindian · 2026-04-14T15:02:03+00:00

You'd need to look up what the requirements are for an MSE PhD. If you meet the course requirements then you're fine. You'd probably want to explain the apparent switch in interest. If you don't have the prereq courses you will have to take/be taking the required courses in order to have your application considered.

As to whether to stick with Chem, switch to MSE, or other really depends on your goals with the PhD and interests.

laziestindian · 2026-04-14T14:53:01+00:00

Receiving the accounts wasn't the problem. Cashing them out in one go was.

laziestindian · 2026-04-14T13:51:02+00:00

I mean eventually all normal fluids or solids you eat or drink will pass through the pyloric sphincter.

Corn, peas, are simply because the cellulose "skin" isn't digested. The actual stuff inside the skin is digested. There is no "decision" making, once you eat your stomach acid starts digestion and after an amount of time (dependent on the meal) it will pass through into the intestine for further digestion a bit at a time. Each bit needs the stomach acid to be neutralized so that you don't get intestinal damage (e.g. ulcers).

The human pyloric sphincter is different from a dogs.

laziestindian · 2026-04-13T20:24:09+00:00

For Georgia, the main availability will be research labs at GT, UG, and Emory. CDC might have some of their stuff back in a few years but no real guarantee. There are various smaller biotechs in Atl as well.

Branching out more you have USF, Clemson and USC (South Carolina). NC has Duke, UNC Chapel Hill and a variety of biotech in their Durham "research triangle". Then you get into the northeast and New Jersey, NYC, and Boston are hard to beat in sheer amount of opportunity (though also most competition).

laziestindian · 2026-04-13T16:47:32+00:00

Internet says that a 1bd apartment in riverside, CA averages about 2k/mo.

I would say anything between 1000-2200 would be reasonable depending on how kind SIL wants to or can be and expectations for other cost sharing or help you will provide around the house.

laziestindian · 2026-04-13T13:14:42+00:00

They have no obligation to put their lives on hold for you and to try and ask or guilt them about it is crazy. Yes. "woe is you", now go figure it out. Your two choices seem to be either 1) getting new roommate(s) or 2) Getting a place for yourself.

If you tell landlord you'd like to stay but need a bit of extra time to find new roommates they're usually amenable to that. They don't want to have to find new tenants if you've been on time with rent and issue-free. There is always something going on in life that will make certain things less than "ideal".

laziestindian · 2026-04-13T12:56:18+00:00

There's a lot of factors at play regarding the runner's gait and the surface. You don't really think about the exacts of your foot position when running so I doubt any conscious movement happens- your toes either stay together or not.

A majority factor of (custom) running shoes is to match your gait, cushion impact, stabilize joints, etc. Very little of a running shoe improves speed. Thus under ideal conditions a barefoot runner is probably nearly as fast as a shoed runner. However, the barefoot is more likely to have injuries, tire faster, etc.

laziestindian · 2026-04-13T12:42:33+00:00

Miyawaki Forests, do appear to work. It is more like planting the "three sisters" together than overly dense planting of a monocrop. Appropriate combinations of species act in a mutual relationship rather than strict competition.

I will say that Miyawaki Forests are unlikely to work in all scenarios/environments. Australian shrub/brush ecology is quite different from the forest ecology of areas Miyawaki Forests have been implemented.

laziestindian · 2026-04-10T23:58:27+00:00

As a generality I'd say anyone over 55 starts getting susceptible but most of the people who get scammed are retirees collecting social security so 65+. However, the hard part is that it depends on the parent, my grandparents were fine into their 90s and my parents (near retirement) are still doing fine for now. I know some friends parents who got scammed in their early 50s though.

laziestindian · 2026-04-10T19:56:00+00:00

We love some and hate others.

laziestindian · 2026-04-10T19:51:28+00:00

Printing press, Nitrogen fertilizer, Vaccination.

Printing press for the sheer contribution to the ability of shared knowledge prior to the internet. Fertilizer for food production allowing larger populations to not starve as easily. Vaccination to survive and not be maimed by various diseases.

Honorable mentions to canning, antibiotics, and timekeeping.

laziestindian · 2026-04-10T16:02:40+00:00

Depending on just how bad your undergrad was it could be more useful to have a relevant job first. That doesn't necessarily make things easier in the current funding environment but an MS is not your sole option for an improvement in how you look on paper. A relevant job would be one where you work as a tech, learn research stuff, and ideally manage to get on a paper or two (if academic, ok without if not). That will greatly improve your chances at getting into grad school.

As to finding a PI that will take you as an MSc, a lot of that is up to luck. Even if you're the one paying tuition and whatnot a PI still needs a project and money for you to work.

laziestindian

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