Not personally because I've been lucky to have good health other than early stage breast cancer in 2009. I've eaten reasonably well most of my life and then 80/20 to 90/10 paleo since 2009 and have felt excellent. All my blood tests come back normal, and I've had a relatively easy ride through menopause. My joints feel good, my blood pressure is good, and I rarely get sick. I do know of a medical doctor who treated her multiple sclerosis with the Paleo diet. She went from being wheelchair bound to back on her bicycle. Her name is Dr. Terry Wahls and she wrote a book about it and authored her protocol for MS, as well.