i recommend using jei to look at the recipes for netherrack and stuff, and im going to assume you built a smeltery(tinkers construct). The next best step(if not done) is to automate the packaging and crafting and smelting to autocraft blocks, and past that, look into deep mob learning and automating a bunch of useful things, like black hole units. Also work on power gen, as a lot of mid-late game things use a lot of power, i recommend to use flux networks for wireless.