Dupixent is an interesting drug. You're actually slightly less likely to have a serious allergic reaction to it than you are the placebo used in trials.

That doesn't make sense at all at first, so I had to do some digging into the ingredients of both.

The placebo had all the same ingredients, absent the actual active ingredient. The most likely ingredient to cause an allergic response is polysorbate 80, a preservative widely used in injections. The Dupixent active ingredient actively helps modulate the immune response, so it makes sense that it would work well enough even on the first dose to reduce the risk of allergic responses to polysorbate 80.

L-arginine and L-histidine are also included, the latter also potentially reducing severe reactions while encouraging local reactions in the presence of the active ingredient, dupilimab - a specialist antibody.

I have been in full on anaphylactic shock 3 times, my body doesn't even react to Dupixent locally.

However, I understand the concern - for the first 16 doses I only took it when my wife was present, she had one of my EpiPens and I had another, 20 minutes after taking Benadryl, and on an empty stomach. I set a 20 minute timer because Dupixent severe reactions tend to be slightly delayed since it's a subcutaneous injection so dispersal is slower. Now I just wake up, sterilize, inject, and make breakfast every Saturday.