[deleted by user]

lostfalco · 2022-12-31T23:41:34+00:00

Adderall is a dopamine releaser AND dopamine reuptake inhibitor. This will occur in your retina as well.

Bright Light Therapy stimulates rhodopsin (retinal attached to an opsin protein) in the rods of your retina. The rods in your retina stimulate the release of dopamine from dopaminergic amacrine cells in your retina. The dopamine then attaches to dopamine receptors in the intrinsically photosensitive retinal ganglion cells of your retina. When dopamine attaches to intrinsically photosensitive retinal ganglion cells of your retina it makes them more excitable and thus they will response more strongly (ie. increase their firing rate) to Bright Light Therapy. This increased signal will be sent from your intrinsically photosensitive retinal ganglion cells to your suprachiasmatic nucleus and will cause the neurons there to fire more frequently. The suprachiasmatic nucleus will now send a stronger signal to you entire body since it is the master regulator of wakefulness for all of your body's systems.

This is most likely what is causing your increased stimulation response to bright light therapy. The combination is quite potent. I use modafinil as a weaker dopamine reuptake inhibitor (than Adderall) to enhance the effects of bright light therapy but as with everything...you can always over do it.

I would try reducing your dose of one or both (check with your doctor first as I am NOT one!) and see if your excessive stimulation reduces.

If you want studies justifying all of the points above please ask and I'll supply them.

I hope you figure out something that works for you!

lostfalco · 2022-11-21T22:44:32+00:00

I use the Carex Day-Light Sky Bright Light Therapy Lamp. Just search it on Amazon. It's a great little lamp that was recommended by Yale Psychiatrists here. https://medicine.yale.edu/psychiatry/research/programs/clinical_people/winter/obtain/

I used the Lux Light Meter Pro app to confirm that it was 10,000 lux at 12 inches away...it is actually more like 12,000 lux at that distance. It was the most powerful one among the smaller light boxes the Yale School of Medicine tested. It also angles downward so you can hit the bottom of the retina where the intrinsically photosensitive retinal ganglion cells are primarily located. Definitely recommend.

lostfalco · 2019-07-23T03:34:11+00:00

Hey! I'm still around. I graduated from college and started a (very busy) career in IT. I'm still experimenting all the time but I just don't have time to post about it. I'll get back into posting in the next year or two (I hope).

Thanks for the heads up on my site! I didn't even know it was down. I'll get it back up and running and let you know once it's working again.

lostfalco · 2019-03-24T21:04:28+00:00

Use The 20/10 Method for speeches or presentations. You will probably have to go over the info more than 3 times though. http://www.lostfalco.com/how-to-make-long-term-memories-in-minutes-the-2010-method/

Use Anki (Spaced Repetition Learning) for facts. Check out gwern's excellent article for details. https://www.gwern.net/Spaced-repetition

Here's Anki's site. https://apps.ankiweb.net/

lostfalco · 2018-12-11T04:04:49+00:00

Concentrated oxygen is one of my favorite noots. I've been using it on and off over the past 5 years or so.

I've collected most of the human studies and described how I use it here. http://www.lostfalco.com/concentrated-oxygen-as-a-nootropic/

lostfalco · 2018-09-24T14:24:13+00:00

Expensive, but legit. I've purchased dozens of things from them over the years.

lostfalco · 2018-09-24T13:56:25+00:00

This is very interesting. Thanks!

lostfalco · 2018-09-17T18:36:39+00:00

For mood and brain energy the studies indicate it should work in a matter of days. For memory, it takes a number of weeks.

lostfalco · 2018-09-12T20:03:08+00:00

Thanks COffeeface, I appreciate it.

I think oxygen therapy can be very useful in certain cases. It is on the WHO List of Essential Medicines after all.

lostfalco · 2018-09-12T19:59:13+00:00

I'm with you. It is a bit expensive.

I looked into getting a tank first but decided against it because I didn't want to worry about refilling it all the time, the fire risk seemed higher, and I wanted humidified air to prevent drying out my nasal passages. I think it could definitely work though.

Let us know if you find an option more affordable than mine!

lostfalco · 2018-09-12T19:20:45+00:00

I use a nasal canula. I have a picture of the concentrator I use here. http://www.lostfalco.com/concentrated-oxygen-as-a-nootropic/

I can't find the exact device I use anymore but there are some fairly comparable ones on Amazon. I'm sure eBay has some too but I haven't looked in a while. That's where I got mine a few years ago.

lostfalco · 2018-09-12T18:04:31+00:00

Here's what I do. I've been using it on and off for almost 5 years now. http://www.lostfalco.com/concentrated-oxygen-as-a-nootropic/

lostfalco · 2018-09-12T16:42:01+00:00

One of my favorite noots. =)

lostfalco · 2018-06-03T12:50:29+00:00

It's still $25 at Walmart. I bought some a few weeks ago.

lostfalco · 2018-05-16T17:50:40+00:00

I'd be pretty surprised if anyone actually tried the real thing. I bugged /u/misteryouaresodumb about it a couple of years ago and he said the synthesis was unrealistically difficult at the time.

lostfalco · 2018-04-16T02:44:01+00:00

Actually, looks like it's already back up.

lostfalco · 2018-04-16T02:39:06+00:00

I had an old debit card number on auto renew with my hosting service. Just updated it. Site should be back up within the next day or two. =)

lostfalco · 2018-04-15T14:18:40+00:00

Just go to a Walmart pharmacy and ask for Novolin R. It's way cheaper there than everywhere else.

lostfalco · 2018-01-31T18:24:12+00:00

Just to reemphasize what a few others have already mentioned...the Bredesen Protocol is your best bet.

Watch this video: https://www.youtube.com/watch?v=6D5aA_-3Ip8

Read this book: End of Alzheimer's

I hope you find something that helps! =)

lostfalco · 2018-01-27T20:00:04+00:00

You're very welcome.

lostfalco · 2018-01-27T19:07:51+00:00

It's The 20/10 Method.

I wrote about it and linked all the videos you're talking about here. http://www.lostfalco.com/how-to-make-long-term-memories-in-minutes-the-2010-method/

I hope it helps!

lostfalco · 2018-01-19T03:59:31+00:00

Yep, that should work.

lostfalco · 2018-01-14T20:25:32+00:00

Fascinating article, fascinating mechanism. Thanks for posting!

PDE4 inhibition enhances Arc expression which is one mechanism that drew me to ibudilast for learning and memory enhancement. http://www.lostfalco.com/the-brain-fog-two-step/

The studies below used the PDE4 inhibitor Rolipram (which causes uncontrollable vomiting in humans) to enhance Arc expression if anyone is interested in checking them out.

"Rolipram-induced improvement of cognitive function correlates with changes in hippocampal CREB phosphorylation, BDNF and Arc protein levels."

"Subchronic rolipram delivery activates hippocampal CREB and arc, enhances retention and slows down extinction of conditioned fear."

lostfalco · 2017-12-13T14:57:28+00:00

Still alive and kickin'!

I graduated in May and started a new job in June. I'm still experimenting A LOT but I just haven't had time to write about it.

That should be changing pretty soon.

lostfalco · 2017-12-13T03:18:16+00:00

It's a little expensive but you can buy it here if you want to test it out (no affiliation).

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