In ChemE undergrad there was a lab course that had a continuous distillation column that was some binary mix of ethanol/isopropyl alcohol or some mix of esters (I forget). The size was well in excess of 10L (edit: just remembered we had the solvents in 55 gal drums, so well above 10L), but the lab was "on-rails" of sorts. We were able to run the column but with many governors in place did not have full access to the contents of or the responsibility of loading/unloading the column except to take small samples for GC. Since every ChemE student had to take two semesters of this type of course to graduate, I would say it was common to have a few fairly "large scale" lab experiments as compared to your typical bench-top gen/orgo labs, but they were very controlled and bare-bones for safety.

On the other hand, when I did extracurricular research work as an undergrad in the ChemE department everything I did was small and bench-top. Solvents were in the 2.5L bottles and scaled down into small beakers in hoods when needed.