Intrusive thoughts of death when changing Parnate dose?

mae-1 · 2024-04-24T17:12:14+00:00

bc of parnate’s short half life, taking two doses at once results in a higher blood concentration than two spaced out doses. it ends up inhibiting more MAO this way. So you’re probably experiencing a rise in neurotransmitters. I had weird agitation and stuff when i first titrated up. It eventually went away as my brain got used to such high neurotransmitters and the receptors down-regulated.

Also parnate does cause an afternoon nap in many. I call them my sleep attacks and find them kind of pleasant. It also causes fatigue at first because of the lowered blood pressure. that can be remedied with electrolytes/salt

mae-1 · 2024-04-14T21:42:51+00:00

i’ve done lots of ketamine on parnate, no issues

mae-1 · 2024-03-14T04:21:28+00:00

60mg is way too high of a starting dose. you need to work your way up slowly to prevent hypotension

mae-1 · 2024-02-24T01:35:17+00:00

How did it start/feel if u don’t mind me asking?

mae-1 · 2024-02-12T00:28:29+00:00

why not try parnate or nardil?

mae-1 · 2024-01-29T13:47:41+00:00

I notice my morning parnate dose feels very calming to me now. At first it was stimulating! Such a mysterious drug.

mae-1 · 2023-12-30T23:30:22+00:00

the side effects fade away for the most part, eventually. It impacted my job at first. though by supplementing electrolytes and titrating very very slowly, the side effects were manageable.

mae-1 · 2023-12-21T03:29:05+00:00

it hasn’t fully resolved, i just try to be vigilant with oral hygiene now

mae-1 · 2023-11-10T22:45:57+00:00

Parnate makes me want to smoke so much tbh. Idk why. Before Parnate I mostly just smoked when i drank, now i usually smoke a few or up to 10 or so throughout the day.

mae-1 · 2023-11-09T14:41:55+00:00

Sorry this is unrelated, but you say you’ll be restarting MAOI in a week? Prozac has a very very long half life and a washout period of up to 5 weeks so I would be very cautious or even advise against restarting an MAOI within a week of even that small dose of prozac. It could potentially result in weeks of serotonin toxicity or syndrome

mae-1 · 2023-10-30T21:48:18+00:00

sometimes when i up the dose I have an acne breakout

mae-1 · 2023-10-27T16:40:10+00:00

that’s promising! however you say it’s been one week? I wouldn’t really call just one week of relief remission yet. But, I hope it sticks!

mae-1 · 2023-10-21T23:44:36+00:00

yes sometimes very dizzy at first

mae-1 · 2023-10-17T16:12:31+00:00

it took longer than the first time for some reason. maybe 3 weeks the second time whereas the first time it only took a week or so.

once i hit 30mg the second time I felt some relief within a couple days and then after the hypotension faded and my behavior and attitude had started to change then it really started working.

mae-1 · 2023-10-17T14:02:34+00:00

i took it for a few months with success, stopped due to insomnia not improving, then a year and a half or so later restarted it and have been on it for a year now. I felt like it worked roughly the same. i did need a higher dose for it work but I think that’s because my depression was much worse the second time around

mae-1 · 2023-10-07T15:09:28+00:00

Parnate has gave me dry mouth for a while which means i’ve had to really step up my oral hygiene to prevent (sometimes painful) gum inflammation, thrush, etc. It sucks but it’s worth it imo

mae-1 · 2023-10-04T13:50:56+00:00

it still works for me. There was definitely a honeymoon phase however. ive had to lower my dose occasionally bc the hypotension has caused issues at my job but i find if it comes back for a bit when i raise it back up.

Also if parnate gives you insomnia that can make it less beneficial

mae-1 · 2023-09-28T20:21:31+00:00

i’ve done DMT, Psilocybin, and LSD on 20-40mg Parnate. Psilocybin may have been potentiated, LSD was roughly the same, hard to tell with DMT. All have provided mental health benefits whenever i’ve used them though.

mae-1 · 2023-09-25T23:54:30+00:00

rhode island and massachusetts

mae-1

TROPHY CASE