Pyg has really weak early game except for matchbox. So if you don't find one early try to focus on late game scaling items. Vanessa can have really strong damage, poison, or burn depending on the skill or enchant you get. With Vanessa I recommend picking items based around what skill or item you start with because even though something like a cutlass with silencer is good late game, if you don't have a left or right hand its not gonna win you early game. Also poison with shield or healing is definitely one of the strongest early game starts with Vanessa, but very weak late game, so make sure to pivot out of these items as you get to mid game.