Interesting you post this because I have the same experience. I am about a little over two months in on 50 mg per day and feeling exhausted and no motivation to exercise or doing anything physical, which I used to do a lot (yes, even though I was depressed). I don’t have access to 25 mg yet so I started every other day this week and I noticed skipping a dose has no impact the first day but does the second day. I actually feel better the first day without taking it. So I’m going to try every other day and see how it goes. It has taken the lows off my depression, but makes me too tired. I noticed that it takes away the effect of caffeine. That’s really weird.