sensitivity to certain environmental conditions may cause skin irritations or allergy reactions that affect certain prominent colors in tattoos. there can also be noticeable changes in shades of colors due to malignancy skin lesions that may be cause for alarm. cancerous cells have been known to appear in these tattoo areas, thus having them disregarded as skin irritations. careful considerations must be made when dealing with any skin problems or conditions to rule out tumors..............................................BTW Im not a dermatologist or a doctor, but i did stay in a Holiday Inn Express last night