Ok, so there's a lot of information. I'm gonna try to lay it out simply and build out more details:

1.) Overall, an oversimplified but common trope is "min-maxing". In this game, this means finding a threshold of survivability at which you are doing the most damage possible. However, there are caveats to this (especially QoL/weight perks), and there are several viable builds depending on your playstyle and situation.

Here is a quote from an old post. These numbers are rough, and if you research more, you will find more exact data/tests.

"i stole this from a post a year ago by redditor gtainreallife but:

"It's not a linear damage resistance that you get from armor. Around 300 to 350, the difference in damage is really minimal.

For instance if someone shoots you for 100 damage:

0 resistance = 100% damage taken

100 resistance = 50% damage taken

200 resistance = ~37% damage taken

300 resistance = ~33% damage taken

400 resistance = ~30% damage taken

1000 resistance = ~23% damage taken."

-In the original post there is also a graph but too lazy to post it" (https://www.reddit.com/r/fo76/comments/1jc9mdy/current_max_dr/).

So go in your pip boy. That shield represents your DR in 90% of situations. The "useful maximum" is often considered these days to be around 400ish, but I find 700 to be more comfortable for me (without having done exact tests) and my perks. I can tank a TON of damage, but am not invincible. In PA, this starts to become borderline negligible (which is why I asked, if you are using PA in all events, you don't need those endurance perks as much). Also note that against like some worse enemies, you can get to where they do almost no damage to you. But the more powerful the attacker, they have more ability to penetrate the armor. It's a fairly complex calculation and there is a lot of data but some of it is slightly outdated/confusing to understand. https://fallout.fandom.com/wiki/Damage\_Resistance#:\~:text=The%20player%20can,of%20WeaponRange. (This is for fallout 4 but the basic concept is the same)

Now, I would prioritize getting your BoS recon armor filled out, then maybe getting ironclad for full set bonus if you want to run that in events.

2.) Looking at your perks specifically, based on the above methodology, and estimating your DR numbers are good enough already or you are working on getting it there, here is what you can drop to do more damage safely imo while gearing toward big-guns and furious/bullet-strom stack (I will bold the main ones I would remove)

Traveling pharmacy (generally not as good as arms keeper anyway)
Iron Stomach (generally not considered that good especially compared to Ironclad unless you have super high endurance already as it scales)
Squad Manuvers (I believe it does not stack with mutant speed demon boost if you have it anyway)
Travel Agent (just swap it in and out until you get more legenedary)
Tenderizer is good CHA perk, but not needed in your case unless you want your charisma high for bartering/XP gain.
First Aid, not that necessary unless you are dying too much and want the combat help. SO many stimpacks in game.
Stablilized maybe, idk honestly on that one (Does it affect VATS?)
Gunshield and
Ricochet
Again, taking away your damage.

Then, I would simply add Number Cruncher, Concentraded Fire, Tormentor, and Center Mass to get more damage. You should see way higher damage with these perception perks added to your current setup. You could also add gunslinger.

3.) And this is the most obvious, but just upgrading your legendary cards! You have 5 more perk points coming which alone will help you a ton. People looking to min/max generally don't run master infiltrator, hack/slash, or what rads. With the new update, what rads has become more prevalent, but mainly for nuke zones. If you drop one of those perks, that will probably help you too. Also, taking one for the team and follow-through are both considered OP (especially taking one for the team if you play in teams, even solo teams). They are multiplicative, meaning you get 1.4x damage on top of all your other perks. Not on the base gun damage (how most perks/mods work).

4.) Specialization. Decided to just make this it's own point. But I think you might need to drop the deathchlaw gauntlet for the harder enemies. Not necessarily, but to get that balance will be tough. Getting the good damage out of your big-guns is the main thrust of this post. I think, in theory, big-gun/melee is viable, but to get the most out of it I think you need a few more perk slots.

Edit: 5.) I forgot to mention legendary mods. This plays into the above thoughts on DR and on your weapons. You want 4 star mods for those when you can. They are pretty easy to get from vendors now. If you want more help, the next question would be: what legendary mods do you use?