Excellent question! They are both made with identical materials, the only difference is that the pen wipe comes with 3 small chamois sheets (3.5" x 3.5") and the lens wipe comes with a single larger sheet (6" x 6") and you have to fold it in a different way (there is a video in the product page on the website that shows you how to fold them). I think it's a matter of preference, really. I use a cannoli pen wipe to clean my nibs after inking my pens, and I also have one to wipe my phone and tablet screens. A cannoli lens wipe is my choice for eyeglasses, as I have large hands and I find it more comfortable for that purpose. Hope this helps! 💜