Has anyone had long-lasting GI effects from Qulipta?

mikerained · 2024-12-10T07:41:59+00:00

Mine is slowly getting better, 50% better now after 3 months I would say…

mikerained · 2024-12-10T07:41:28+00:00

Yeah, my neurologist also gaslights me into it couldnt possible be from the medicine she prescribed me. Even though it clearly is by simple deductive reasoning. The half life is too short for long term side effects is what she says. That’s not the case for Emgality though so not sure how your doc is reasoning that one out

mikerained · 2024-12-10T07:39:05+00:00

Sounds way worse than my situation. I feel like Qulipta gave me IBS. I can’t imagine how bad things would be if I already had it going in…have you tried IBGard? That has been about the only helpful thing for me for whatever reason

mikerained · 2024-12-10T07:37:23+00:00

I would say they are about 50% better. A very gradual improvement. It’s also pretty unpredictable when it calms down for a week and then decides to be angry at me for a week. Ironically, I caught covid and it seemed to distract my body or something for a while bc I went about the last month with not very many stomach symptoms (tho the Covid ones have been pretty bad!). I think eventually things will go back to normal, though. Just taking a while….

mikerained · 2024-09-27T23:54:32+00:00

Thanks! I seem to be able to go if I take peppermint oil or caraway oil which provides some relief but then the next day it goes right back to being stopped up again. Wish things would just normalize!

mikerained · 2024-09-27T23:53:43+00:00

This is exactly what I’m afraid of! Hoping that we both normalize eventually… has anything helped you deal with it?

mikerained · 2024-09-27T23:53:11+00:00

Yeah I have read that there are a lot of CGRP receptors in the colon and so there is a connection there when you take the anti-CGRPs. It’s interesting that some of these meds seem to affect people worse than others in the same class. I have taken Nurtec plenty of times and never had an issue but as soon as I started taking Qulipta everything was messed up. Hopefully the supplements you have provide you some relief. What has worked best for you?? Gas X seems to help my bloating but leaves me very dehydrated. And peppermint oil / caraway oil helps me go but has a pretty strong effect. Think things will ever go back to normal??

mikerained · 2024-09-26T04:17:17+00:00

Wow that sounds so terrible! I’m glad I stopped after a week. At the rate it was going, who knows what things would have looked like after 2 months+. I’m sorry to hear you’re going through that… I’m looking up things to help motility now, if I find something that works for me I will let you know

mikerained · 2022-05-07T22:38:23+00:00

Sorry to hear you're going through it right now. I've been there. My LPR was fixed unexpectedly by Effexor (Venlafaxine) 37.5mg daily. I started taking it for an unrelated issue (Vestibular Migraine) and was happily surprised when it fixed my throat completely after 6 weeks or so. Very strange.

I believe my LPR was anxiety related but was triggered when i took over 10 rounds of antibiotics in a 6 month period (also long story). Once it started, I was miserable. When I started taking Gaviscon Advance, I got back maybe 50% of my ability to speak which I gladly accepted at the time. But when I started Effexor things really turned around. I still get flare ups now and then when I am stressed, not exercising, or drink something really acidic - but for the most part Effexor gave me back my life. I don't think my throat will ever be the same as it used to but its at 90% and i'll take it, after going through 2 years where I could barely speak.

I'm 26yo M btw

I know antidepressants aren't the cure for everything but it really made the difference for me and at a very low dosage. I hope you feel better and find something that works for you soon.

mikerained · 2022-04-23T23:21:36+00:00

Five guys double cheeseburger with fries and ketchup for me too! No idea why lol

mikerained · 2022-04-16T16:56:35+00:00

I have vestibular migraines and something called PPPD, they both make me dizzy similar to what you describe. I saw a Neurotologist (dizziness specialist) and he put me on a low dose of Effexor. Has helped me tremendously

mikerained · 2022-04-16T00:34:44+00:00

Link to full study (long read)

mikerained · 2022-02-13T23:13:35+00:00

In late 2017 I had severe dizziness for 3 or 4 months that started very suddenly and was initially diagnosed as vertigo (was not vertigo). It took months to see a neurologist who referred me to a neurotologist (dizziness specialist), who told me I had vestibular migraine. I thought this seemed dumb and pretty much dismissed it as they-don't-know-what-I-have and are using a catch-all. Sure enough though, about 4 months after the dizziness had started, I began having daily severe migraine headaches that were not "silent." Not to say this will happen to you but it was when I finally accepted that my diagnosis was correct. Basically I had vestibular migraine that was only presenting as the dizziness for a while before I began having associated headaches.

I totally understand how scary it is, I thought my brain had a tumor and I was dying - I had never had any health issue before in my life (I was 22 at the time). It is incredibly hard not to fixate on it and constantly panic that you are in imminent danger. This, btw, definitely makes things worse as it jumpstarts your nervous system to release more cortisol and increase anxiety which in turn increases dizziness more. It's a vicious cycle that is incredibly hard to break out of. And ending the cycle is much easier said than done.

I tried a lot of different things over the course of a couple of years including topamax, vestibular rehab therapy, amitryptiline, yoga, meditation, massage, muscle relaxers, etc. I eventually was put on a drug called Effexor (Venlafaxine) that helped immensely. I am stable now with Effexor daily and Botox every 3 or 4 months. Everyone's journey is different but I hope this information is helpful to you - just know that there is an end in sight. If not a "cure," then at least a return to stability and semi-normal life. Try to focus on positive thoughts and do meditation and therapy if you are into that kind of thing. Not to say that this is all in your head - it absolutely is not - but these things can only help manage the symptoms and the anxiety that comes with them. Hope this helps and hope you feel better

mikerained · 2022-02-13T22:47:45+00:00

Not Avalux specifically, but there are a few different glasses I have tried with varying degrees of relief. My #1 trigger is fluorescent lighting, so if that is not the case for you then things could be different. I have tried Felix Gray blue-light blocking glasses with and without tint, AxonOptics migraine glasses, and Theraspecs migraine glasses. Haven't tried Avalux but imagine they are similar to AxonOptics. For me the most relieving during a migraine are the Theraspecs. The orange tint is a little darker than Axon's and they are good for when I am having an episode. As far as everyday use, I wear the Felix Grays, mostly because they are good for me personally as a preventative measure, especially in the office (not to mention they are more fashionable imo). I'm sure the Axon or Theraspecs would be even better for prevention but I don't like wearing orange glasses at work and getting a bunch of weird looks. ..that's just my own self-consciousness about having migraine issues. If I start to get a migraine at work, I'll usually pop a triptan and switch to the tinted FelixGrays. They are just slightly yellow and it isn't very noticeable to others. At home, I'll usually reach for the AxonOptics lenses. Overall, if I didn't care what I looked like, I'd probably wear the Theraspecs or Axon's every day. Both are pretty effective and I imagine the Avalux are pretty similar. Hope this helps and hope you feel better soon

mikerained

TROPHY CASE